Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 925677..926331 Replicon chromosome
Accession NZ_CP120568
Organism Escherichia coli strain 582

Toxin (Protein)


Gene name cptA Uniprot ID S1PAM6
Locus tag P5711_RS04545 Protein ID WP_000244781.1
Coordinates 925924..926331 (+) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S1PPB1
Locus tag P5711_RS04540 Protein ID WP_000354046.1
Coordinates 925677..925943 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P5711_RS04515 (920965) 920965..921708 + 744 WP_000951964.1 SDR family oxidoreductase -
P5711_RS04520 (921765) 921765..923198 - 1434 WP_046952425.1 6-phospho-beta-glucosidase BglA -
P5711_RS04525 (923243) 923243..923554 + 312 WP_001182954.1 N(4)-acetylcytidine aminohydrolase -
P5711_RS04530 (923718) 923718..924377 + 660 WP_000250274.1 hemolysin III family protein -
P5711_RS04535 (924454) 924454..925434 - 981 WP_000886083.1 tRNA-modifying protein YgfZ -
P5711_RS04540 (925677) 925677..925943 + 267 WP_000354046.1 FAD assembly factor SdhE Antitoxin
P5711_RS04545 (925924) 925924..926331 + 408 WP_000244781.1 protein YgfX Toxin
P5711_RS04550 (926371) 926371..926892 - 522 WP_044863754.1 flavodoxin FldB -
P5711_RS04555 (927004) 927004..927900 + 897 WP_000806638.1 site-specific tyrosine recombinase XerD -
P5711_RS04560 (927925) 927925..928635 + 711 WP_000715214.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
P5711_RS04565 (928641) 928641..930374 + 1734 WP_000813201.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 16061.99 Da        Isoelectric Point: 11.5202

>T275208 WP_000244781.1 NZ_CP120568:925924-926331 [Escherichia coli]
VVLWQSDLRVSWRAQWLSLLIHGLVAAVILLMPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEIRLLMDGRLRWQGQ
EWSIVKAPWMIKSGMMLRLRSDSGKRQHLWLAADSMDEAEWRDLRRILLQQETQR

Download         Length: 408 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10547.12 Da        Isoelectric Point: 5.1599

>AT275208 WP_000354046.1 NZ_CP120568:925677-925943 [Escherichia coli]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRIFIRLLECDDPDLFNWLMNHGKPADAELEMMVRLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1PAM6

Antitoxin

Source ID Structure
PDB 6B58
PDB 1X6I
PDB 1X6J
PDB 6C12
AlphaFold DB A0A7U9QD57

References