Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type V Classification (family/domain) ghoTS/ghoT-GhoS
Location 4839898..4840395 Replicon chromosome
Accession NZ_CP120567
Organism Escherichia coli strain A0 34/86

Toxin (Protein)


Gene name ghoT Uniprot ID L4JJG6
Locus tag P5707_RS23510 Protein ID WP_001173343.1
Coordinates 4839898..4840071 (-) Length 58 a.a.

Antitoxin (Protein)


Gene name ghoS Uniprot ID S1NQ59
Locus tag P5707_RS23515 Protein ID WP_001312331.1
Coordinates 4840099..4840395 (-) Length 99 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P5707_RS23500 (4836568) 4836568..4838025 + 1458 WP_000856826.1 dipeptide/tripeptide permease DtpC -
P5707_RS23505 (4838262) 4838262..4839779 + 1518 WP_000003805.1 lysine--tRNA ligase -
P5707_RS23510 (4839898) 4839898..4840071 - 174 WP_001173343.1 type V toxin-antitoxin system toxin GhoT Toxin
P5707_RS23515 (4840099) 4840099..4840395 - 297 WP_001312331.1 type V toxin-antitoxin system endoribonuclease antitoxin GhoS Antitoxin
P5707_RS23520 (4840624) 4840624..4840896 - 273 WP_000405647.1 GNAT family N-acetyltransferase -
P5707_RS23525 (4840908) 4840908..4841138 - 231 WP_001683478.1 4Fe-4S mono-cluster protein YjdI -
P5707_RS23530 (4841319) 4841319..4842950 + 1632 WP_001216466.1 sensor histidine kinase -
P5707_RS23535 (4842947) 4842947..4843666 + 720 WP_000611291.1 two-component system response regulator DcuR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin GhoT/OrtT

(4-57)

Antitoxin

Endoribonuclease antitoxin GhoS

(5-94)


Sequences

Toxin        


Download         Length: 58 a.a.        Molecular weight: 6555.06 Da        Isoelectric Point: 10.2288

>T275204 WP_001173343.1 NZ_CP120567:c4840071-4839898 [Escherichia coli]
MALFSKILIFYVIGVNISFVIIWFISHEKTHIRLLSAFLVGITWPMSLPVALLFSLF

Download         Length: 174 bp

Antitoxin


Download         Length: 99 a.a.        Molecular weight: 11440.95 Da        Isoelectric Point: 4.1705

>AT275204 WP_001312331.1 NZ_CP120567:c4840395-4840099 [Escherichia coli]
MEGKNKFNTYVVSFDYPSSYSSVFLRLRSLMYDMNFSSIVADEYGIPRQLNENSFAITTSLAASEIEDLIRLKCLDLPDI
DFDLSIMTVDDYFRQFYK

Download         Length: 297 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9QI41

Antitoxin

Source ID Structure
AlphaFold DB S1NQ59

References