Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3940348..3940966 Replicon chromosome
Accession NZ_CP120567
Organism Escherichia coli strain A0 34/86

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag P5707_RS19180 Protein ID WP_001291435.1
Coordinates 3940748..3940966 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag P5707_RS19175 Protein ID WP_000344800.1
Coordinates 3940348..3940722 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P5707_RS19165 (3935438) 3935438..3936631 + 1194 WP_001295833.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
P5707_RS19170 (3936654) 3936654..3939803 + 3150 WP_001132480.1 efflux RND transporter permease AcrB -
P5707_RS19175 (3940348) 3940348..3940722 + 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
P5707_RS19180 (3940748) 3940748..3940966 + 219 WP_001291435.1 HHA domain-containing protein Toxin
P5707_RS19185 (3941140) 3941140..3941691 + 552 WP_000102539.1 maltose O-acetyltransferase -
P5707_RS19190 (3941807) 3941807..3942277 + 471 WP_000136192.1 YlaC family protein -
P5707_RS19195 (3942441) 3942441..3943991 + 1551 WP_001298569.1 cyclic-guanylate-specific phosphodiesterase PdeB -
P5707_RS19200 (3944033) 3944033..3944386 - 354 WP_000878138.1 DUF1428 family protein -
P5707_RS19210 (3944765) 3944765..3945076 + 312 WP_000409908.1 MGMT family protein -
P5707_RS19215 (3945107) 3945107..3945679 - 573 WP_000779830.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T275196 WP_001291435.1 NZ_CP120567:3940748-3940966 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT275196 WP_000344800.1 NZ_CP120567:3940348-3940722 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References