Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 2788996..2790584 Replicon chromosome
Accession NZ_CP120567
Organism Escherichia coli strain A0 34/86

Toxin (Protein)


Gene name hipA Uniprot ID A0A192ENQ5
Locus tag P5707_RS13535 Protein ID WP_001125432.1
Coordinates 2789262..2790584 (+) Length 441 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID V0VAH2
Locus tag P5707_RS13530 Protein ID WP_001304368.1
Coordinates 2788996..2789262 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P5707_RS13515 (2785364) 2785364..2786815 + 1452 WP_000854637.1 tagaturonate reductase -
P5707_RS13520 (2787012) 2787012..2787926 + 915 WP_001298637.1 bestrophin family protein -
P5707_RS13525 (2787930) 2787930..2788688 - 759 WP_001286538.1 trans-aconitate 2-methyltransferase -
P5707_RS13530 (2788996) 2788996..2789262 + 267 WP_001304368.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
P5707_RS13535 (2789262) 2789262..2790584 + 1323 WP_001125432.1 type II toxin-antitoxin system serine/threonine protein kinase toxin HipA Toxin
P5707_RS13540 (2790974) 2790974..2791549 - 576 Protein_2641 LysR family transcriptional regulator -
P5707_RS13545 (2791599) 2791599..2791934 + 336 Protein_2642 SDR family NAD(P)-dependent oxidoreductase -
P5707_RS13550 (2792178) 2792178..2792285 - 108 Protein_2643 hypothetical protein -
P5707_RS13555 (2792710) 2792710..2793273 + 564 WP_001296074.1 type 1 fimbrial major subunit FimA -
P5707_RS13560 (2793635) 2793635..2794345 + 711 WP_001195180.1 fimbria/pilus periplasmic chaperone -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(4-103)

Antitoxin

Cro/C1-type helix-turn-helix domain

(14-69)


Sequences

Toxin        


Download         Length: 441 a.a.        Molecular weight: 49297.02 Da        Isoelectric Point: 8.6972

>T275192 WP_001125432.1 NZ_CP120567:2789262-2790584 [Escherichia coli]
MPKLVTWMNNQRVGELTKLANGAHTFKYAPEWLASRYARPLSLSLPLQRGNITSDAVFNFFDNLLPDSPIVRDRIVKRYH
AKSRQPFDLLSEIGRDSVGAVTLIPEDETVTCPIMAWEKLTEARLEEVLTAYKADIPLGMIREENDFRISVAGAQEKTAL
LRIGNDWCIPKGITPTTHIIKLPIGEIRQPNATLDLSQSVDNEYYCLLLAKELGLNVPDAEIIKAGRVRALAVKRFDRRW
NTERTVLLRLPQEDMCQTFGLPSSVKYESDGGPGIAQIMAFLMGSSEALKDRYDFMKFQVFQWLIGATDGHAKNFSVFIQ
AGGSYRLTPFYDIISAFPVLGGTGIHISDLKLAMGLNASKGKKTAIDKIYPRHFLATAKVLKFPEVQMHEILSDFARMIP
AALDNVKTSLPTDFPENVVTAVETNVLRLHGRLSREYGIK

Download         Length: 1323 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9957.31 Da        Isoelectric Point: 4.9632

>AT275192 WP_001304368.1 NZ_CP120567:2788996-2789262 [Escherichia coli]
MMSFQKIYSPTQLANAMKLVRQQNGWTQSELAKKIGIKQATISNFENNPDNTSLTTFFKILQSLELSMTLCDAKNASPEA
AEQQDLEW

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A192ENQ5

Antitoxin

Source ID Structure
AlphaFold DB V0VAH2

References