275185

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/PRK09907-MazE
Location 1381558..1382141 Replicon chromosome
Accession NZ_CP120567
Organism Escherichia coli strain A0 34/86

Toxin (Protein)


Gene name mazF Uniprot ID V0SV58
Locus tag P5707_RS06540 Protein ID WP_000254750.1
Coordinates 1381806..1382141 (+) Length 112 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID S1P3W5
Locus tag P5707_RS06535 Protein ID WP_000581937.1
Coordinates 1381558..1381806 (+) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P5707_RS06525 (1377897) 1377897..1379198 + 1302 WP_000046817.1 23S rRNA (uracil(1939)-C(5))-methyltransferase RlmD -
P5707_RS06530 (1379246) 1379246..1381480 + 2235 WP_000226815.1 GTP pyrophosphokinase -
P5707_RS06535 (1381558) 1381558..1381806 + 249 WP_000581937.1 type II toxin-antitoxin system antitoxin MazE Antitoxin
P5707_RS06540 (1381806) 1381806..1382141 + 336 WP_000254750.1 endoribonuclease MazF Toxin
P5707_RS06545 (1382213) 1382213..1383004 + 792 WP_001071677.1 nucleoside triphosphate pyrophosphohydrolase -
P5707_RS06550 (1383232) 1383232..1384869 + 1638 WP_000210888.1 CTP synthase (glutamine hydrolyzing) -
P5707_RS06555 (1384957) 1384957..1386255 + 1299 WP_000036723.1 phosphopyruvate hydratase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(10-109)

Antitoxin

SpoVT-AbrB domain

(7-51)


Sequences

Toxin        


Download         Length: 112 a.a.        Molecular weight: 12067.95 Da        Isoelectric Point: 8.2618

>T275185 WP_000254750.1 NZ_CP120567:1381806-1382141 [Escherichia coli]
MVSRYVPDTGDLIWVDFDPTKGSEQAGHRPAVVLSPFMYNNKTGMCLCVPCTTQSKGYPFEVVLSGQERDGVALADQVKS
IAWRARGATKKGTVAPEELQLIKAKINVLIG

Download         Length: 336 bp

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9355.74 Da        Isoelectric Point: 4.4665

>AT275185 WP_000581937.1 NZ_CP120567:1381558-1381806 [Escherichia coli]
MIHSSVKRWGNSPAVRIPATLMQALNLNIDDEVKIDLVDGKLIIEPVRKEPVFTLAELVNDITPENLHENIDWGEPKDKE
VW

Download         Length: 249 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB V0SV58

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LMB4

References