Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 1228942..1229581 Replicon chromosome
Accession NZ_CP120567
Organism Escherichia coli strain A0 34/86

Toxin (Protein)


Gene name cptA Uniprot ID -
Locus tag P5707_RS05915 Protein ID WP_021521010.1
Coordinates 1229189..1229581 (+) Length 131 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S1PPB1
Locus tag P5707_RS05910 Protein ID WP_000354046.1
Coordinates 1228942..1229208 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P5707_RS05890 (1225030) 1225030..1226463 - 1434 WP_001350137.1 6-phospho-beta-glucosidase BglA -
P5707_RS05895 (1226508) 1226508..1226819 + 312 WP_001182956.1 N(4)-acetylcytidine aminohydrolase -
P5707_RS05900 (1226983) 1226983..1227642 + 660 WP_000250274.1 hemolysin III family protein -
P5707_RS05905 (1227719) 1227719..1228699 - 981 WP_000886078.1 tRNA-modifying protein YgfZ -
P5707_RS05910 (1228942) 1228942..1229208 + 267 WP_000354046.1 FAD assembly factor SdhE Antitoxin
P5707_RS05915 (1229189) 1229189..1229581 + 393 WP_021521010.1 protein YgfX Toxin
P5707_RS05920 (1229636) 1229636..1230157 - 522 WP_001055874.1 flavodoxin FldB -
P5707_RS05925 (1230269) 1230269..1231165 + 897 WP_000806638.1 site-specific tyrosine recombinase XerD -
P5707_RS05930 (1231190) 1231190..1231900 + 711 WP_000715230.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
P5707_RS05935 (1231906) 1231906..1233639 + 1734 WP_021521009.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-130)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 131 a.a.        Molecular weight: 15419.32 Da        Isoelectric Point: 11.5439

>T275184 WP_021521010.1 NZ_CP120567:1229189-1229581 [Escherichia coli]
VVLWQSDLRVSWRAQWLSLLIHGLVAAVILLMPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEIRLLMDGRLRWQGQ
EWSIVKAPWMIKSGMMLRLRSDSGKRQHLWLAADSMDEAEWRDLRRILLQ

Download         Length: 393 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10547.12 Da        Isoelectric Point: 5.1599

>AT275184 WP_000354046.1 NZ_CP120567:1228942-1229208 [Escherichia coli]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRIFIRLLECDDPDLFNWLMNHGKPADAELEMMVRLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
PDB 6B58
PDB 1X6I
PDB 1X6J
PDB 6C12
AlphaFold DB A0A7U9QD57

References