Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 1081781..1082579 Replicon chromosome
Accession NZ_CP120567
Organism Escherichia coli strain A0 34/86

Toxin (Protein)


Gene name yeeV Uniprot ID -
Locus tag P5707_RS05190 Protein ID WP_057916008.1
Coordinates 1081781..1082158 (-) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A1L4NTN5
Locus tag P5707_RS05195 Protein ID WP_001605875.1
Coordinates 1082205..1082579 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P5707_RS05160 (1076909) 1076909..1078057 - 1149 WP_000905920.1 capsule polysaccharide export inner-membrane protein KpsE -
P5707_RS05165 (1078129) 1078129..1079112 - 984 WP_001336760.1 KpsF/GutQ family sugar-phosphate isomerase -
P5707_RS05170 (1079923) 1079923..1080093 - 171 Protein_1005 IS110 family transposase -
P5707_RS05175 (1080435) 1080435..1081277 - 843 WP_112065071.1 DUF4942 domain-containing protein -
P5707_RS05180 (1081362) 1081362..1081559 - 198 WP_112065078.1 DUF957 domain-containing protein -
P5707_RS05185 (1081635) 1081635..1081784 - 150 Protein_1008 DUF5983 family protein -
P5707_RS05190 (1081781) 1081781..1082158 - 378 WP_057916008.1 TA system toxin CbtA family protein Toxin
P5707_RS05195 (1082205) 1082205..1082579 - 375 WP_001605875.1 type IV toxin-antitoxin system cytoskeleton bundling-enhancing antitoxin CbeA Antitoxin
P5707_RS05200 (1082653) 1082653..1082874 - 222 WP_000692303.1 DUF987 domain-containing protein -
P5707_RS05205 (1082943) 1082943..1083419 - 477 WP_057916007.1 RadC family protein -
P5707_RS05210 (1083435) 1083435..1083920 - 486 WP_001536436.1 antirestriction protein -
P5707_RS05215 (1084012) 1084012..1084830 - 819 WP_001234393.1 DUF932 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 14140.14 Da        Isoelectric Point: 7.2652

>T275183 WP_057916008.1 NZ_CP120567:c1082158-1081781 [Escherichia coli]
MKTLPDTHVREASCCPSPVTIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATSLMTRDNYRTVNNITLGKHPEAKQ

Download         Length: 378 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 13594.42 Da        Isoelectric Point: 5.4554

>AT275183 WP_001605875.1 NZ_CP120567:c1082579-1082205 [Escherichia coli]
VSDTLPGTTLPDDNHDRPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGLFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLACEADTLGSCGYVYMAVYPTLAPATTS

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A1L4NTN5

References