Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 67091..67716 Replicon plasmid pH22_122286
Accession NZ_CP120564
Organism Escherichia coli strain H22

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag P5708_RS24920 Protein ID WP_000911317.1
Coordinates 67318..67716 (+) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID L4J1D2
Locus tag P5708_RS24915 Protein ID WP_000450532.1
Coordinates 67091..67318 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P5708_RS24915 (67091) 67091..67318 + 228 WP_000450532.1 toxin-antitoxin system antitoxin VapB Antitoxin
P5708_RS24920 (67318) 67318..67716 + 399 WP_000911317.1 type II toxin-antitoxin system VapC family toxin Toxin
P5708_RS24925 (67725) 67725..69878 - 2154 WP_024186499.1 type IV conjugative transfer system coupling protein TraD -
P5708_RS24930 (70104) 70104..70892 - 789 WP_019842748.1 hypothetical protein -
P5708_RS24935 (71102) 71102..71413 + 312 WP_019842747.1 heavy metal-binding domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid - iroB / iroC / iroD / iroE / iroN / papD / papC 1..122286 122286


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-125)

Antitoxin

SpoVT-AbrB domain

(7-51)


Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14857.14 Da        Isoelectric Point: 8.5264

>T275176 WP_000911317.1 NZ_CP120564:67318-67716 [Escherichia coli]
MLKFMLDTNICIFTIKNKPASVRERFNLNQGRMCISSVTLMELIYGAEKSQMPERNLAVIEGFVSRIDVLDYDAAAATHT
GQIRAELARQGRPVGPFDQMIAGHARSRGLIIVTNNTREFERVGGLRIEDWS

Download         Length: 399 bp

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8512.55 Da        Isoelectric Point: 4.5358

>AT275176 WP_000450532.1 NZ_CP120564:67091-67318 [Escherichia coli]
METTVFLSNRSQAVRLPKAVALPENVKRVEVIAVGRTRIITPAGETWDEWFDGNSVSADFMDNREQPGMQERESF

Download         Length: 228 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A829CHF5

References