Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) relBE/RHH(antitoxin)
Location 44169..44722 Replicon plasmid pH22_122286
Accession NZ_CP120564
Organism Escherichia coli strain H22

Toxin (Protein)


Gene name relE Uniprot ID S1PMX5
Locus tag P5708_RS24780 Protein ID WP_000421257.1
Coordinates 44169..44444 (-) Length 92 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag P5708_RS24785 Protein ID WP_019842653.1
Coordinates 44444..44722 (-) Length 93 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P5708_RS24755 (40035) 40035..41519 - 1485 WP_097419528.1 alpha/beta hydrolase -
P5708_RS24760 (41704) 41704..42654 - 951 WP_107131109.1 omptin family outer membrane protease -
P5708_RS24765 (42979) 42979..43104 + 126 Protein_42 efflux transporter periplasmic adaptor subunit -
P5708_RS24770 (43108) 43108..43344 - 237 WP_137498364.1 colicin V immunity protein -
P5708_RS24775 (43860) 43860..44063 - 204 Protein_44 hypothetical protein -
P5708_RS24780 (44169) 44169..44444 - 276 WP_000421257.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
P5708_RS24785 (44444) 44444..44722 - 279 WP_019842653.1 ribbon-helix-helix domain-containing protein Antitoxin
P5708_RS24790 (44809) 44809..45595 - 787 Protein_47 IS21 family transposase -
P5708_RS24795 (45717) 45717..46064 - 348 WP_019842650.1 DUF6404 family protein -
P5708_RS24800 (46183) 46183..46530 + 348 WP_001595228.1 colicin E1 family microcin immunity protein -
P5708_RS24805 (46548) 46548..48428 - 1881 WP_277708340.1 colicin Ia central receptor-binding domain-containing protein -
P5708_RS24810 (48669) 48669..48872 + 204 Protein_51 hypothetical protein -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid - iroB / iroC / iroD / iroE / iroN / papD / papC 1..122286 122286


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.



Sequences


Toxin        


Download         Length: 92 a.a.        Molecular weight: 10749.45 Da        Isoelectric Point: 9.9324

>T275173 WP_000421257.1 NZ_CP120564:c44444-44169 [Escherichia coli]
MELKWTSKALSDLARLYDFLVLASKPAAARTVQSLTQAPVILLTHPRMGEQLFQFEPREVRRIFAGEYEIRYELNGQTIY
VLRLWHTRENR

Download         Length: 276 bp


Antitoxin


Download         Length: 93 a.a.        Molecular weight: 10225.59 Da        Isoelectric Point: 5.6558

>AT275173 WP_019842653.1 NZ_CP120564:c44722-44444 [Escherichia coli]
MKNNTAQATKVITAHVPLPMADKVDQIAARLERSRGWIIKQALSAWLAQEEERNRLTLEALDDVTSGQIIDHQAVQAWAD
SLSTDNPLPVPR

Download         Length: 279 bp


Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB S1PMX5


Antitoxin

Source ID Structure

References