Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type V Classification (family/domain) ghoTS/ghoT-GhoS
Location 4512379..4512876 Replicon chromosome
Accession NZ_CP120563
Organism Escherichia coli strain H22

Toxin (Protein)


Gene name ghoT Uniprot ID L4JJG6
Locus tag P5708_RS22190 Protein ID WP_001173343.1
Coordinates 4512379..4512552 (-) Length 58 a.a.

Antitoxin (Protein)


Gene name ghoS Uniprot ID S1NQ59
Locus tag P5708_RS22195 Protein ID WP_001312331.1
Coordinates 4512580..4512876 (-) Length 99 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P5708_RS22180 (4509049) 4509049..4510506 + 1458 WP_000856826.1 dipeptide/tripeptide permease DtpC -
P5708_RS22185 (4510743) 4510743..4512260 + 1518 WP_000003805.1 lysine--tRNA ligase -
P5708_RS22190 (4512379) 4512379..4512552 - 174 WP_001173343.1 type V toxin-antitoxin system toxin GhoT Toxin
P5708_RS22195 (4512580) 4512580..4512876 - 297 WP_001312331.1 type V toxin-antitoxin system endoribonuclease antitoxin GhoS Antitoxin
P5708_RS22200 (4513105) 4513105..4513377 - 273 WP_000405647.1 GNAT family N-acetyltransferase -
P5708_RS22205 (4513389) 4513389..4513619 - 231 WP_000373291.1 4Fe-4S mono-cluster protein YjdI -
P5708_RS22210 (4513800) 4513800..4515431 + 1632 WP_001216466.1 sensor histidine kinase -
P5708_RS22215 (4515428) 4515428..4516147 + 720 WP_000611288.1 two-component system response regulator DcuR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 4492608..4512876 20268


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin GhoT/OrtT

(4-57)

Antitoxin

Endoribonuclease antitoxin GhoS

(5-94)


Sequences

Toxin        


Download         Length: 58 a.a.        Molecular weight: 6555.06 Da        Isoelectric Point: 10.2288

>T275171 WP_001173343.1 NZ_CP120563:c4512552-4512379 [Escherichia coli]
MALFSKILIFYVIGVNISFVIIWFISHEKTHIRLLSAFLVGITWPMSLPVALLFSLF

Download         Length: 174 bp

Antitoxin


Download         Length: 99 a.a.        Molecular weight: 11440.95 Da        Isoelectric Point: 4.1705

>AT275171 WP_001312331.1 NZ_CP120563:c4512876-4512580 [Escherichia coli]
MEGKNKFNTYVVSFDYPSSYSSVFLRLRSLMYDMNFSSIVADEYGIPRQLNENSFAITTSLAASEIEDLIRLKCLDLPDI
DFDLSIMTVDDYFRQFYK

Download         Length: 297 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9QI41

Antitoxin

Source ID Structure
AlphaFold DB S1NQ59

References