Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3587686..3588304 Replicon chromosome
Accession NZ_CP120563
Organism Escherichia coli strain H22

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag P5708_RS17710 Protein ID WP_001291435.1
Coordinates 3588086..3588304 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag P5708_RS17705 Protein ID WP_000344800.1
Coordinates 3587686..3588060 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P5708_RS17695 (3582776) 3582776..3583969 + 1194 WP_001538394.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
P5708_RS17700 (3583992) 3583992..3587141 + 3150 WP_001132480.1 efflux RND transporter permease AcrB -
P5708_RS17705 (3587686) 3587686..3588060 + 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
P5708_RS17710 (3588086) 3588086..3588304 + 219 WP_001291435.1 HHA domain-containing protein Toxin
P5708_RS17715 (3588477) 3588477..3589028 + 552 WP_000102539.1 maltose O-acetyltransferase -
P5708_RS17720 (3589144) 3589144..3589614 + 471 WP_000136192.1 YlaC family protein -
P5708_RS17725 (3589778) 3589778..3591328 + 1551 WP_089638034.1 cyclic-guanylate-specific phosphodiesterase PdeB -
P5708_RS17730 (3591370) 3591370..3591723 - 354 WP_000878140.1 DUF1428 domain-containing protein -
P5708_RS17740 (3592102) 3592102..3592413 + 312 WP_000409908.1 MGMT family protein -
P5708_RS17745 (3592444) 3592444..3593016 - 573 WP_000779831.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T275166 WP_001291435.1 NZ_CP120563:3588086-3588304 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT275166 WP_000344800.1 NZ_CP120563:3587686-3588060 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References