Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 2514632..2516220 Replicon chromosome
Accession NZ_CP120563
Organism Escherichia coli strain H22

Toxin (Protein)


Gene name hipA Uniprot ID A0A192ENQ5
Locus tag P5708_RS12340 Protein ID WP_001125432.1
Coordinates 2514898..2516220 (+) Length 441 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID V0VAH2
Locus tag P5708_RS12335 Protein ID WP_001304368.1
Coordinates 2514632..2514898 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P5708_RS12320 (2511000) 2511000..2512451 + 1452 WP_000854637.1 tagaturonate reductase -
P5708_RS12325 (2512648) 2512648..2513562 + 915 WP_001313828.1 bestrophin family protein -
P5708_RS12330 (2513566) 2513566..2514324 - 759 WP_001286588.1 trans-aconitate 2-methyltransferase -
P5708_RS12335 (2514632) 2514632..2514898 + 267 WP_001304368.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
P5708_RS12340 (2514898) 2514898..2516220 + 1323 WP_001125432.1 type II toxin-antitoxin system serine/threonine protein kinase toxin HipA Toxin
P5708_RS12345 (2516530) 2516530..2516937 - 408 Protein_2420 acetylxylan esterase -
P5708_RS12350 (2516940) 2516940..2517521 - 582 Protein_2421 LysR family transcriptional regulator -
P5708_RS12355 (2517670) 2517670..2518452 + 783 WP_001221834.1 SDR family oxidoreductase -
P5708_RS12360 (2518696) 2518696..2518803 - 108 Protein_2423 hypothetical protein -
P5708_RS12365 (2519228) 2519228..2519791 + 564 WP_001296074.1 type 1 fimbrial major subunit FimA -
P5708_RS12370 (2520153) 2520153..2520863 + 711 WP_001195181.1 fimbria/pilus periplasmic chaperone -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(4-103)

Antitoxin

Cro/C1-type helix-turn-helix domain

(14-69)


Sequences

Toxin        


Download         Length: 441 a.a.        Molecular weight: 49297.02 Da        Isoelectric Point: 8.6972

>T275164 WP_001125432.1 NZ_CP120563:2514898-2516220 [Escherichia coli]
MPKLVTWMNNQRVGELTKLANGAHTFKYAPEWLASRYARPLSLSLPLQRGNITSDAVFNFFDNLLPDSPIVRDRIVKRYH
AKSRQPFDLLSEIGRDSVGAVTLIPEDETVTCPIMAWEKLTEARLEEVLTAYKADIPLGMIREENDFRISVAGAQEKTAL
LRIGNDWCIPKGITPTTHIIKLPIGEIRQPNATLDLSQSVDNEYYCLLLAKELGLNVPDAEIIKAGRVRALAVKRFDRRW
NTERTVLLRLPQEDMCQTFGLPSSVKYESDGGPGIAQIMAFLMGSSEALKDRYDFMKFQVFQWLIGATDGHAKNFSVFIQ
AGGSYRLTPFYDIISAFPVLGGTGIHISDLKLAMGLNASKGKKTAIDKIYPRHFLATAKVLKFPEVQMHEILSDFARMIP
AALDNVKTSLPTDFPENVVTAVETNVLRLHGRLSREYGIK

Download         Length: 1323 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9957.31 Da        Isoelectric Point: 4.9632

>AT275164 WP_001304368.1 NZ_CP120563:2514632-2514898 [Escherichia coli]
MMSFQKIYSPTQLANAMKLVRQQNGWTQSELAKKIGIKQATISNFENNPDNTSLTTFFKILQSLELSMTLCDAKNASPEA
AEQQDLEW

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A192ENQ5

Antitoxin

Source ID Structure
AlphaFold DB V0VAH2

References