Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 963040..963694 Replicon chromosome
Accession NZ_CP120563
Organism Escherichia coli strain H22

Toxin (Protein)


Gene name cptA Uniprot ID S1PAM6
Locus tag P5708_RS04735 Protein ID WP_000244781.1
Coordinates 963287..963694 (+) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S1PPB1
Locus tag P5708_RS04730 Protein ID WP_000354046.1
Coordinates 963040..963306 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P5708_RS04710 (959118) 959118..960551 - 1434 WP_001350137.1 6-phospho-beta-glucosidase BglA -
P5708_RS04715 (960596) 960596..960907 + 312 WP_001182956.1 N(4)-acetylcytidine aminohydrolase -
P5708_RS04720 (961071) 961071..961730 + 660 WP_000250274.1 hemolysin III family protein -
P5708_RS04725 (961807) 961807..962787 - 981 WP_021513792.1 tRNA-modifying protein YgfZ -
P5708_RS04730 (963040) 963040..963306 + 267 WP_000354046.1 FAD assembly factor SdhE Antitoxin
P5708_RS04735 (963287) 963287..963694 + 408 WP_000244781.1 protein YgfX Toxin
P5708_RS04740 (963734) 963734..964255 - 522 WP_001055874.1 flavodoxin FldB -
P5708_RS04745 (964367) 964367..965263 + 897 WP_000806638.1 site-specific tyrosine recombinase XerD -
P5708_RS04750 (965288) 965288..965998 + 711 WP_000715230.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
P5708_RS04755 (966004) 966004..967737 + 1734 WP_042020700.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 16061.99 Da        Isoelectric Point: 11.5202

>T275156 WP_000244781.1 NZ_CP120563:963287-963694 [Escherichia coli]
VVLWQSDLRVSWRAQWLSLLIHGLVAAVILLMPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEIRLLMDGRLRWQGQ
EWSIVKAPWMIKSGMMLRLRSDSGKRQHLWLAADSMDEAEWRDLRRILLQQETQR

Download         Length: 408 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10547.12 Da        Isoelectric Point: 5.1599

>AT275156 WP_000354046.1 NZ_CP120563:963040-963306 [Escherichia coli]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRIFIRLLECDDPDLFNWLMNHGKPADAELEMMVRLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1PAM6

Antitoxin

Source ID Structure
PDB 6B58
PDB 1X6I
PDB 1X6J
PDB 6C12
AlphaFold DB A0A7U9QD57

References