Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RHH(antitoxin)
Location 18074..18633 Replicon plasmid pB771_95480
Accession NZ_CP120559
Organism Escherichia coli strain B771

Toxin (Protein)


Gene name relE Uniprot ID A0A733EV64
Locus tag P5709_RS25745 Protein ID WP_001582571.1
Coordinates 18358..18633 (+) Length 92 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID C1J8K5
Locus tag P5709_RS25740 Protein ID WP_001178089.1
Coordinates 18074..18358 (+) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P5709_RS25720 (13721) 13721..14254 - 534 WP_001303319.1 transcription termination/antitermination NusG family protein -
P5709_RS25725 (14696) 14696..14983 - 288 WP_000074849.1 conjugal transfer protein TraA -
P5709_RS25730 (14901) 14901..15131 - 231 WP_228772074.1 ash family protein -
P5709_RS25735 (16137) 16137..17168 + 1032 WP_000907875.1 plasmid replication initiator RepA -
P5709_RS25740 (18074) 18074..18358 + 285 WP_001178089.1 ribbon-helix-helix domain-containing protein Antitoxin
P5709_RS25745 (18358) 18358..18633 + 276 WP_001582571.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
P5709_RS25750 (18739) 18739..18942 + 204 Protein_21 hypothetical protein -
P5709_RS25755 (19212) 19212..19478 - 267 WP_000627829.1 hypothetical protein -
P5709_RS25760 (19478) 19478..19972 - 495 WP_001582574.1 hypothetical protein -
P5709_RS25765 (20028) 20028..20630 - 603 WP_000517695.1 ProQ/FINO family protein -
P5709_RS25770 (20984) 20984..22399 + 1416 WP_029397060.1 protein YagA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid blaTEM-1B - 1..95480 95480


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-90)

Antitoxin

Ribbon-helix-helix protein, CopG

(14-51)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10807.48 Da        Isoelectric Point: 9.5296

>T275149 WP_001582571.1 NZ_CP120559:18358-18633 [Escherichia coli]
MELKWTSKALSDLARLYDFLVLASKPAAARTVQSLTQAPVILLTHPRMGEQLFQFEPREVRRIFAGEYEIRYELNDQTIY
VLRLWHTRENR

Download         Length: 276 bp

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10474.89 Da        Isoelectric Point: 5.6558

>AT275149 WP_001178089.1 NZ_CP120559:18074-18358 [Escherichia coli]
MQMKNNTAQATKVITAHVPLPMADKVDQMAARLERSRGWVIKQALSAWLAQEEERNRLTLEALDDVTSGQVIDHQAVQAW
ADSLSTDNPLPVPR

Download         Length: 285 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A733EV64

Antitoxin

Source ID Structure
AlphaFold DB A0A731IHA8

References