Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 4663386..4664004 Replicon chromosome
Accession NZ_CP120557
Organism Escherichia coli strain B771

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag P5709_RS22690 Protein ID WP_001291435.1
Coordinates 4663386..4663604 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag P5709_RS22695 Protein ID WP_000344800.1
Coordinates 4663630..4664004 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P5709_RS22655 (4658675) 4658675..4659247 + 573 WP_000779826.1 YbaY family lipoprotein -
P5709_RS22660 (4659278) 4659278..4659589 - 312 WP_000409911.1 MGMT family protein -
P5709_RS22670 (4659968) 4659968..4660321 + 354 WP_000878140.1 DUF1428 domain-containing protein -
P5709_RS22675 (4660363) 4660363..4661913 - 1551 WP_001299455.1 cyclic-guanylate-specific phosphodiesterase PdeB -
P5709_RS22680 (4662077) 4662077..4662547 - 471 WP_000136192.1 YlaC family protein -
P5709_RS22685 (4662663) 4662663..4663214 - 552 WP_000102564.1 maltose O-acetyltransferase -
P5709_RS22690 (4663386) 4663386..4663604 - 219 WP_001291435.1 HHA domain-containing protein Toxin
P5709_RS22695 (4663630) 4663630..4664004 - 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
P5709_RS22700 (4664550) 4664550..4667699 - 3150 WP_001132469.1 efflux RND transporter permease AcrB -
P5709_RS22705 (4667722) 4667722..4668915 - 1194 WP_001295324.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T275143 WP_001291435.1 NZ_CP120557:c4663604-4663386 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT275143 WP_000344800.1 NZ_CP120557:c4664004-4663630 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References