Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type V Classification (family/domain) ghoTS/ghoT-GhoS
Location 3307218..3307715 Replicon chromosome
Accession NZ_CP120557
Organism Escherichia coli strain B771

Toxin (Protein)


Gene name ghoT Uniprot ID L4JJG6
Locus tag P5709_RS16290 Protein ID WP_001173343.1
Coordinates 3307218..3307391 (-) Length 58 a.a.

Antitoxin (Protein)


Gene name ghoS Uniprot ID L4JK92
Locus tag P5709_RS16295 Protein ID WP_000398619.1
Coordinates 3307419..3307715 (-) Length 99 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P5709_RS16280 (3303888) 3303888..3305345 + 1458 WP_000856841.1 dipeptide/tripeptide permease DtpC -
P5709_RS16285 (3305582) 3305582..3307099 + 1518 WP_001295090.1 lysine--tRNA ligase -
P5709_RS16290 (3307218) 3307218..3307391 - 174 WP_001173343.1 type V toxin-antitoxin system toxin GhoT Toxin
P5709_RS16295 (3307419) 3307419..3307715 - 297 WP_000398619.1 type V toxin-antitoxin system endoribonuclease antitoxin GhoS Antitoxin
P5709_RS16300 (3307942) 3307942..3308214 - 273 WP_000405651.1 GNAT family N-acetyltransferase -
P5709_RS16305 (3308226) 3308226..3308456 - 231 WP_029490320.1 4Fe-4S mono-cluster protein YjdI -
P5709_RS16310 (3308637) 3308637..3310268 + 1632 WP_001216477.1 sensor histidine kinase -
P5709_RS16315 (3310265) 3310265..3310984 + 720 WP_000611288.1 two-component system response regulator DcuR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin GhoT/OrtT

(4-57)

Antitoxin

Endoribonuclease antitoxin GhoS

(5-94)


Sequences

Toxin        


Download         Length: 58 a.a.        Molecular weight: 6555.06 Da        Isoelectric Point: 10.2288

>T275138 WP_001173343.1 NZ_CP120557:c3307391-3307218 [Escherichia coli]
MALFSKILIFYVIGVNISFVIIWFISHEKTHIRLLSAFLVGITWPMSLPVALLFSLF

Download         Length: 174 bp

Antitoxin


Download         Length: 99 a.a.        Molecular weight: 11467.97 Da        Isoelectric Point: 4.1705

>AT275138 WP_000398619.1 NZ_CP120557:c3307715-3307419 [Escherichia coli]
MEGKNKFNTYVVSFDYPSSYSSVFLRLRSLMYDMNFSSIVADEYGIPRQLNENSFAITTSLAASEIEDLIRLKCLDLPDI
DFDLNIMTVDDYFRQFYK

Download         Length: 297 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9QI41

Antitoxin

Source ID Structure
PDB 2LLZ
AlphaFold DB A0A7U9QBH6

References