Detailed information of TA system
Overview
TA module
| Type | IV | Classification (family/domain) | yeeUV (cbtA-cbeA)/CbtA-CbeA |
| Location | 3295435..3296304 | Replicon | chromosome |
| Accession | NZ_CP120557 | ||
| Organism | Escherichia coli strain B771 | ||
Toxin (Protein)
| Gene name | yeeV | Uniprot ID | A0A0U4BLW2 |
| Locus tag | P5709_RS16245 | Protein ID | WP_059309235.1 |
| Coordinates | 3295894..3296304 (+) | Length | 137 a.a. |
Antitoxin (Protein)
| Gene name | yeeU | Uniprot ID | A0A0X5FMN2 |
| Locus tag | P5709_RS16240 | Protein ID | WP_039023579.1 |
| Coordinates | 3295435..3295803 (+) | Length | 123 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| P5709_RS16210 (3291513) | 3291513..3292397 | + | 885 | WP_000010380.1 | YfjP family GTPase | - |
| P5709_RS16215 (3292583) | 3292583..3293401 | + | 819 | WP_001234689.1 | DUF932 domain-containing protein | - |
| P5709_RS16220 (3293483) | 3293483..3293962 | + | 480 | WP_000860074.1 | antirestriction protein | - |
| P5709_RS16225 (3293978) | 3293978..3294454 | + | 477 | WP_001366830.1 | RadC family protein | - |
| P5709_RS16230 (3294517) | 3294517..3294738 | + | 222 | WP_000692315.1 | DUF987 domain-containing protein | - |
| P5709_RS16235 (3294753) | 3294753..3295385 | + | 633 | Protein_3191 | antitoxin of toxin-antitoxin stability system | - |
| P5709_RS16240 (3295435) | 3295435..3295803 | + | 369 | WP_039023579.1 | type IV toxin-antitoxin system YeeU family antitoxin | Antitoxin |
| P5709_RS16245 (3295894) | 3295894..3296304 | + | 411 | WP_059309235.1 | TA system toxin CbtA family protein | Toxin |
| P5709_RS16250 (3296267) | 3296267..3296416 | + | 150 | Protein_3194 | DUF5983 family protein | - |
| P5709_RS16255 (3296492) | 3296492..3296689 | + | 198 | WP_085975623.1 | DUF957 domain-containing protein | - |
| P5709_RS16260 (3296774) | 3296774..3297615 | + | 842 | Protein_3196 | DUF4942 domain-containing protein | - |
| P5709_RS16265 (3298364) | 3298364..3299902 | + | 1539 | WP_001187177.1 | lysine decarboxylation/transport transcriptional activator CadC | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 137 a.a. Molecular weight: 15234.33 Da Isoelectric Point: 6.8522
>T275137 WP_059309235.1 NZ_CP120557:3295894-3296304 [Escherichia coli]
MKLLPDTHVREASCCPSPVTIWQTLLIRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SAGAPSQLINSIDILRARRATGLMTRNNYRMVNNITLGSIRGRNDETFPDAGSRQH
MKLLPDTHVREASCCPSPVTIWQTLLIRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SAGAPSQLINSIDILRARRATGLMTRNNYRMVNNITLGSIRGRNDETFPDAGSRQH
Download Length: 411 bp
Antitoxin
Download Length: 123 a.a. Molecular weight: 13672.49 Da Isoelectric Point: 6.7393
>AT275137 WP_039023579.1 NZ_CP120557:3295435-3295803 [Escherichia coli]
VSDTLSGITHPDDNHDRPWWGLPCTVRPCFGARLVQEGNRLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCEADTLGSCGYVYLAVYPTPETKK
VSDTLSGITHPDDNHDRPWWGLPCTVRPCFGARLVQEGNRLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCEADTLGSCGYVYLAVYPTPETKK
Download Length: 369 bp
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A0U4BLW2 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A0X5FMN2 |