Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 2358832..2359486 Replicon chromosome
Accession NZ_CP120557
Organism Escherichia coli strain B771

Toxin (Protein)


Gene name cptA Uniprot ID A0A140N853
Locus tag P5709_RS11675 Protein ID WP_000244783.1
Coordinates 2358832..2359239 (-) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S1PPB1
Locus tag P5709_RS11680 Protein ID WP_000354046.1
Coordinates 2359220..2359486 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P5709_RS11655 (2354789) 2354789..2356522 - 1734 WP_000813212.1 single-stranded-DNA-specific exonuclease RecJ -
P5709_RS11660 (2356528) 2356528..2357238 - 711 WP_000715216.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
P5709_RS11665 (2357263) 2357263..2358159 - 897 WP_000806638.1 site-specific tyrosine recombinase XerD -
P5709_RS11670 (2358271) 2358271..2358792 + 522 WP_001055874.1 flavodoxin FldB -
P5709_RS11675 (2358832) 2358832..2359239 - 408 WP_000244783.1 protein YgfX Toxin
P5709_RS11680 (2359220) 2359220..2359486 - 267 WP_000354046.1 FAD assembly factor SdhE Antitoxin
P5709_RS11685 (2359729) 2359729..2360709 + 981 WP_000886062.1 tRNA-modifying protein YgfZ -
P5709_RS11690 (2360905) 2360905..2361564 - 660 WP_000250274.1 hemolysin III family protein -
P5709_RS11695 (2361728) 2361728..2362039 - 312 WP_001182954.1 N(4)-acetylcytidine aminohydrolase -
P5709_RS11700 (2362084) 2362084..2363517 + 1434 WP_001338826.1 6-phospho-beta-glucosidase BglA -
P5709_RS11705 (2363574) 2363574..2364317 - 744 WP_000951948.1 SDR family oxidoreductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 15962.85 Da        Isoelectric Point: 11.2669

>T275133 WP_000244783.1 NZ_CP120557:c2359239-2358832 [Escherichia coli]
VVLWQSDLRVSWRAQWLSLLIHGLVAAVILLMPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEISLLMDGRLRWQGQ
EWSIVKAPWMIKSGMMLRLRSDGGKRQHLWLAADSMDEAEWRDLRRILLQQETQR

Download         Length: 408 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10547.12 Da        Isoelectric Point: 5.1599

>AT275133 WP_000354046.1 NZ_CP120557:c2359486-2359220 [Escherichia coli]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRIFIRLLECDDPDLFNWLMNHGKPADAELEMMVRLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A140N853

Antitoxin

Source ID Structure
PDB 6B58
PDB 1X6I
PDB 1X6J
PDB 6C12
AlphaFold DB A0A7U9QD57

References