Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/UPF0150(antitoxin)
Location 736663..737301 Replicon chromosome
Accession NZ_CP120557
Organism Escherichia coli strain B771

Toxin (Protein)


Gene name hicA Uniprot ID S1F9G9
Locus tag P5709_RS03880 Protein ID WP_000813794.1
Coordinates 736663..736839 (+) Length 59 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag P5709_RS03885 Protein ID WP_001270286.1
Coordinates 736885..737301 (+) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P5709_RS03860 (732282) 732282..733457 - 1176 WP_277715399.1 BenE family transporter YdcO -
P5709_RS03865 (733549) 733549..734085 + 537 WP_000429155.1 DNA-binding transcriptional regulator SutR -
P5709_RS03870 (734158) 734158..736119 + 1962 WP_001301045.1 23S rRNA 5-hydroxycytidine C2501 synthase -
P5709_RS03875 (736211) 736211..736441 - 231 WP_000494244.1 YncJ family protein -
P5709_RS03880 (736663) 736663..736839 + 177 WP_000813794.1 type II toxin-antitoxin system mRNA interferase toxin HicA Toxin
P5709_RS03885 (736885) 736885..737301 + 417 WP_001270286.1 type II toxin-antitoxin system antitoxin HicB Antitoxin
P5709_RS03890 (737380) 737380..738786 + 1407 WP_000760626.1 PLP-dependent aminotransferase family protein -
P5709_RS03895 (739031) 739031..740176 + 1146 WP_000047424.1 ABC transporter substrate-binding protein -
P5709_RS03900 (740194) 740194..741207 + 1014 WP_000220396.1 ABC transporter ATP-binding protein -
P5709_RS03905 (741208) 741208..742149 + 942 WP_001251313.1 ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-57)

Antitoxin

Cro/C1-type helix-turn-helix domain

(91-134)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6749.83 Da        Isoelectric Point: 11.2298

>T275124 WP_000813794.1 NZ_CP120557:736663-736839 [Escherichia coli]
VKQSEFRRWLESQGVDVANGSNHLKLRFHGRRSVMPRHPCDEIKEPLRKAILKQLGLS

Download         Length: 177 bp

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 15246.63 Da        Isoelectric Point: 4.7386

>AT275124 WP_001270286.1 NZ_CP120557:736885-737301 [Escherichia coli]
MRYPVTLTPAPEGGYMVSFVDIPEALTQGETVAEAMEAAKDALLTAFDFYFEDNELIPLPSPLNSHDHFIEVPLSVASKV
LLLNAFLQSEITQQELARRIGKPKQEITRLFNLHHATKIDAVQLAAKALGKELSLVMV

Download         Length: 417 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6HPB

Antitoxin

Source ID Structure

References