Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 120375..121209 Replicon chromosome
Accession NZ_CP120557
Organism Escherichia coli strain B771

Toxin (Protein)


Gene name yeeV Uniprot ID W0S379
Locus tag P5709_RS00680 Protein ID WP_000854808.1
Coordinates 120832..121209 (+) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID -
Locus tag P5709_RS00675 Protein ID WP_277715387.1
Coordinates 120375..120743 (+) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P5709_RS00650 (117491) 117491..118309 + 819 WP_001234702.1 DUF932 domain-containing protein -
P5709_RS00655 (118400) 118400..118885 + 486 WP_000214317.1 antirestriction protein -
P5709_RS00660 (118900) 118900..119376 + 477 WP_001384029.1 RadC family protein -
P5709_RS00665 (119445) 119445..119666 + 222 WP_000692353.1 DUF987 domain-containing protein -
P5709_RS00670 (119681) 119681..120325 + 645 WP_277715386.1 antitoxin of toxin-antitoxin stability system -
P5709_RS00675 (120375) 120375..120743 + 369 WP_277715387.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
P5709_RS00680 (120832) 120832..121209 + 378 WP_000854808.1 type IV toxin-antitoxin system cytoskeleton-binding toxin CbtA Toxin
P5709_RS00685 (121206) 121206..121694 + 489 WP_039022338.1 DUF5983 family protein -
P5709_RS00690 (121706) 121706..121903 + 198 WP_029396577.1 DUF957 domain-containing protein -
P5709_RS00695 (121988) 121988..122830 + 843 WP_175109877.1 DUF4942 domain-containing protein -
P5709_RS00705 (123322) 123322..123540 - 219 WP_001040187.1 translation initiation factor IF-1 -
P5709_RS00710 (123825) 123825..124529 - 705 WP_001241678.1 leucyl/phenylalanyl-tRNA--protein transferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 13909.93 Da        Isoelectric Point: 7.9085

>T275120 WP_000854808.1 NZ_CP120557:120832-121209 [Escherichia coli]
MKTLPVLPGQAASSRPSPVEIWQILLSRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTHSQLINSIDILRARRATGLMTRDNYRTVNNITLGKHPGAKQ

Download         Length: 378 bp

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13716.61 Da        Isoelectric Point: 7.3713

>AT275120 WP_277715387.1 NZ_CP120557:120375-120743 [Escherichia coli]
VSDTLSGITHPDDNHDRPWWGLPCTVRPCFGARLVQEGNQLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYARGLTCKADTLSSCGYVYLAVYPTPKMKN

Download         Length: 369 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB W0S379

Antitoxin

Source ID Structure

References