Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vagCD/VapC-VagC
Location 131103..131746 Replicon plasmid pB1172_153456
Accession NZ_CP120550
Organism Escherichia coli strain B1172

Toxin (Protein)


Gene name vagD Uniprot ID V0UN72
Locus tag P5710_RS25620 Protein ID WP_001034044.1
Coordinates 131330..131746 (+) Length 139 a.a.

Antitoxin (Protein)


Gene name vagC Uniprot ID B1P7N7
Locus tag P5710_RS25615 Protein ID WP_001261286.1
Coordinates 131103..131333 (+) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P5710_RS25600 (P5710_25600) 126240..126470 + 231 WP_001261278.1 type II toxin-antitoxin system VapB family antitoxin -
P5710_RS25605 (P5710_25605) 126467..126883 + 417 WP_001034046.1 type II toxin-antitoxin system VapC family toxin -
P5710_RS25610 (P5710_25610) 126928..130722 - 3795 WP_001144732.1 hypothetical protein -
P5710_RS25615 (P5710_25615) 131103..131333 + 231 WP_001261286.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
P5710_RS25620 (P5710_25620) 131330..131746 + 417 WP_001034044.1 type II toxin-antitoxin system VapC family toxin Toxin
P5710_RS25625 (P5710_25625) 131821..133386 + 1566 WP_001128474.1 AAA family ATPase -
P5710_RS25630 (P5710_25630) 133371..134393 + 1023 WP_000361402.1 helicase UvrD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid sitABCD iroB / iroC / iroD / iroE / iroN / vat / vat / iutA / iucD / iucC / iucB / iucA 1..153456 153456
- flank IS/Tn - - 134647..135150 503


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-129)

Antitoxin

SpoVT-AbrB domain

(7-52)


Sequences

Toxin        


Download         Length: 139 a.a.        Molecular weight: 15232.66 Da        Isoelectric Point: 6.8536

>T275119 WP_001034044.1 NZ_CP120550:131330-131746 [Escherichia coli]
VNKIYMLDTNICSFIMREQPEALLKHLEQSVLRGHRIVVSAITYSEMRFGATGPKASPRHVQLVDAFCERLDAVLPWDRA
AVDATTEIKVALRLAGTPIGPNDTAIAGHAIAACAILVTNNVREFERVPGLVLEDWVR

Download         Length: 417 bp

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8747.86 Da        Isoelectric Point: 4.3775

>AT275119 WP_001261286.1 NZ_CP120550:131103-131333 [Escherichia coli]
MRTVSIFKNGNNRAIRLPRDLDFEGVSELEIVREGDSIILRPVRPTWGSFLELEKADPDFMTEREDVVSDEGRVNL

Download         Length: 231 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829CHW1

Antitoxin

Source ID Structure
AlphaFold DB A0A829CKZ6

References