Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 83795..84420 Replicon plasmid pB1172_153456
Accession NZ_CP120550
Organism Escherichia coli strain B1172

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag P5710_RS25325 Protein ID WP_000911313.1
Coordinates 84022..84420 (+) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID V0VCB2
Locus tag P5710_RS25320 Protein ID WP_000450520.1
Coordinates 83795..84022 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P5710_RS25320 (P5710_25320) 83795..84022 + 228 WP_000450520.1 toxin-antitoxin system antitoxin VapB Antitoxin
P5710_RS25325 (P5710_25325) 84022..84420 + 399 WP_000911313.1 type II toxin-antitoxin system VapC family toxin Toxin
P5710_RS25330 (P5710_25330) 84429..86582 - 2154 WP_053879280.1 type IV conjugative transfer system coupling protein TraD -
P5710_RS25335 (P5710_25335) 86834..87565 - 732 WP_000850423.1 conjugal transfer complement resistance protein TraT -
P5710_RS25340 (P5710_25340) 87579..88088 - 510 WP_000628105.1 conjugal transfer entry exclusion protein TraS -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid sitABCD iroB / iroC / iroD / iroE / iroN / vat / vat / iutA / iucD / iucC / iucB / iucA 1..153456 153456


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-125)

Antitoxin

SpoVT-AbrB domain

(8-50)


Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14901.15 Da        Isoelectric Point: 7.8605

>T275116 WP_000911313.1 NZ_CP120550:84022-84420 [Escherichia coli]
MLKFMLDTNICIFTIKNKPASVRERFNLNQGRMCISSVTLMELIYGAEKSQMPERNLAVIEGFVSRIDVLDYDAAAATHS
GQIRAELARQGRPVGPFDQMIAGHARSRGLIIVTNNTREFERVDGLRIEDWS

Download         Length: 399 bp

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8596.63 Da        Isoelectric Point: 4.7513

>AT275116 WP_000450520.1 NZ_CP120550:83795-84022 [Escherichia coli]
METTVFFSNRSQAVRLPKAVALPENVKRVEVIAVGRTRIITPAGETWDEWFDGHNVSADFMDNREQPGMQERESF

Download         Length: 228 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB V0VCB2

References