Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type V Classification (family/domain) ghoTS/ghoT-GhoS
Location 4598625..4599122 Replicon chromosome
Accession NZ_CP120549
Organism Escherichia coli strain B1172

Toxin (Protein)


Gene name ghoT Uniprot ID L4JJG6
Locus tag P5710_RS22320 Protein ID WP_001173343.1
Coordinates 4598625..4598798 (-) Length 58 a.a.

Antitoxin (Protein)


Gene name ghoS Uniprot ID S1NQ59
Locus tag P5710_RS22325 Protein ID WP_001312331.1
Coordinates 4598826..4599122 (-) Length 99 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P5710_RS22300 (4593957) 4593957..4595414 + 1458 WP_000856825.1 dipeptide/tripeptide permease DtpC -
P5710_RS22305 (4595651) 4595651..4596304 + 654 Protein_4371 OB-fold nucleic acid binding domain-containing protein -
P5710_RS22310 (4596318) 4596318..4597526 - 1209 WP_001339175.1 IS4-like element ISVsa5 family transposase -
P5710_RS22315 (4597634) 4597634..4598506 + 873 Protein_4373 lysine--tRNA ligase -
P5710_RS22320 (4598625) 4598625..4598798 - 174 WP_001173343.1 type V toxin-antitoxin system toxin GhoT Toxin
P5710_RS22325 (4598826) 4598826..4599122 - 297 WP_001312331.1 type V toxin-antitoxin system endoribonuclease antitoxin GhoS Antitoxin
P5710_RS22330 (4599351) 4599351..4599623 - 273 WP_000405647.1 GNAT family N-acetyltransferase -
P5710_RS22335 (4599635) 4599635..4599865 - 231 WP_000371704.1 4Fe-4S mono-cluster protein YjdI -
P5710_RS22340 (4600046) 4600046..4601677 + 1632 WP_001216466.1 sensor histidine kinase -
P5710_RS22345 (4601674) 4601674..4602393 + 720 WP_000611288.1 two-component system response regulator DcuR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 4596318..4597526 1208


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin GhoT/OrtT

(4-57)

Antitoxin

Endoribonuclease antitoxin GhoS

(5-94)


Sequences

Toxin        


Download         Length: 58 a.a.        Molecular weight: 6555.06 Da        Isoelectric Point: 10.2288

>T275114 WP_001173343.1 NZ_CP120549:c4598798-4598625 [Escherichia coli]
MALFSKILIFYVIGVNISFVIIWFISHEKTHIRLLSAFLVGITWPMSLPVALLFSLF

Download         Length: 174 bp

Antitoxin


Download         Length: 99 a.a.        Molecular weight: 11440.95 Da        Isoelectric Point: 4.1705

>AT275114 WP_001312331.1 NZ_CP120549:c4599122-4598826 [Escherichia coli]
MEGKNKFNTYVVSFDYPSSYSSVFLRLRSLMYDMNFSSIVADEYGIPRQLNENSFAITTSLAASEIEDLIRLKCLDLPDI
DFDLSIMTVDDYFRQFYK

Download         Length: 297 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9QI41

Antitoxin

Source ID Structure
AlphaFold DB S1NQ59

References