Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3652566..3653184 Replicon chromosome
Accession NZ_CP120549
Organism Escherichia coli strain B1172

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag P5710_RS17675 Protein ID WP_001291435.1
Coordinates 3652966..3653184 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag P5710_RS17670 Protein ID WP_000344800.1
Coordinates 3652566..3652940 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P5710_RS17660 (3647656) 3647656..3648849 + 1194 WP_001295833.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
P5710_RS17665 (3648872) 3648872..3652021 + 3150 WP_001132480.1 efflux RND transporter permease AcrB -
P5710_RS17670 (3652566) 3652566..3652940 + 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
P5710_RS17675 (3652966) 3652966..3653184 + 219 WP_001291435.1 HHA domain-containing protein Toxin
P5710_RS17680 (3653358) 3653358..3653909 + 552 WP_000102539.1 maltose O-acetyltransferase -
P5710_RS17685 (3654025) 3654025..3654495 + 471 WP_000136192.1 YlaC family protein -
P5710_RS17690 (3654659) 3654659..3656209 + 1551 WP_001298569.1 cyclic-guanylate-specific phosphodiesterase PdeB -
P5710_RS17695 (3656251) 3656251..3656604 - 354 WP_000878140.1 DUF1428 domain-containing protein -
P5710_RS17705 (3656983) 3656983..3657294 + 312 WP_000409908.1 MGMT family protein -
P5710_RS17710 (3657325) 3657325..3657897 - 573 WP_000779831.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T275108 WP_001291435.1 NZ_CP120549:3652966-3653184 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT275108 WP_000344800.1 NZ_CP120549:3652566-3652940 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References