Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 999087..999741 Replicon chromosome
Accession NZ_CP120549
Organism Escherichia coli strain B1172

Toxin (Protein)


Gene name cptA Uniprot ID S1PAM6
Locus tag P5710_RS04875 Protein ID WP_000244781.1
Coordinates 999334..999741 (+) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S1PPB1
Locus tag P5710_RS04870 Protein ID WP_000354046.1
Coordinates 999087..999353 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P5710_RS04850 (995175) 995175..996608 - 1434 WP_001350137.1 6-phospho-beta-glucosidase BglA -
P5710_RS04855 (996653) 996653..996964 + 312 WP_001182956.1 N(4)-acetylcytidine aminohydrolase -
P5710_RS04860 (997128) 997128..997787 + 660 WP_000250274.1 hemolysin III family protein -
P5710_RS04865 (997864) 997864..998844 - 981 WP_000886078.1 tRNA-modifying protein YgfZ -
P5710_RS04870 (999087) 999087..999353 + 267 WP_000354046.1 FAD assembly factor SdhE Antitoxin
P5710_RS04875 (999334) 999334..999741 + 408 WP_000244781.1 protein YgfX Toxin
P5710_RS04880 (999781) 999781..1000302 - 522 WP_001055874.1 flavodoxin FldB -
P5710_RS04885 (1000414) 1000414..1001310 + 897 WP_000806633.1 site-specific tyrosine recombinase XerD -
P5710_RS04890 (1001335) 1001335..1002045 + 711 WP_000715230.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
P5710_RS04895 (1002051) 1002051..1003784 + 1734 WP_000813193.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 16061.99 Da        Isoelectric Point: 11.5202

>T275098 WP_000244781.1 NZ_CP120549:999334-999741 [Escherichia coli]
VVLWQSDLRVSWRAQWLSLLIHGLVAAVILLMPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEIRLLMDGRLRWQGQ
EWSIVKAPWMIKSGMMLRLRSDSGKRQHLWLAADSMDEAEWRDLRRILLQQETQR

Download         Length: 408 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10547.12 Da        Isoelectric Point: 5.1599

>AT275098 WP_000354046.1 NZ_CP120549:999087-999353 [Escherichia coli]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRIFIRLLECDDPDLFNWLMNHGKPADAELEMMVRLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1PAM6

Antitoxin

Source ID Structure
PDB 6B58
PDB 1X6I
PDB 1X6J
PDB 6C12
AlphaFold DB A0A7U9QD57

References