Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 1200668..1201469 Replicon chromosome
Accession NC_017651
Organism Escherichia coli str. clone D i2

Toxin (Protein)


Gene name yeeV Uniprot ID A0A0H2V687
Locus tag I02_RS05815 Protein ID WP_000854739.1
Coordinates 1201089..1201469 (+) Length 127 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A0P7R0L9
Locus tag I02_RS05810 Protein ID WP_001285482.1
Coordinates 1200668..1201042 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I02_RS05775 1196756..1197211 + 456 WP_000581502.1 hypothetical protein -
I02_RS28165 1197330..1197541 - 212 Protein_1095 hypothetical protein -
I02_RS05785 1197622..1198443 + 822 WP_001234710.1 DUF945 domain-containing protein -
I02_RS05790 1198706..1199179 + 474 WP_000855076.1 antirestriction protein -
I02_RS05795 1199195..1199671 + 477 WP_001186170.1 RadC family protein -
I02_RS05800 1199734..1199955 + 222 WP_000692312.1 DUF987 domain-containing protein -
I02_RS05805 1199974..1200618 + 645 WP_000094915.1 hypothetical protein -
I02_RS05810 1200668..1201042 + 375 WP_001285482.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
I02_RS05815 1201089..1201469 + 381 WP_000854739.1 TA system toxin CbtA family protein Toxin
I02_RS05820 1201466..1201954 + 489 WP_001054232.1 hypothetical protein -
I02_RS05825 1201974..1202171 + 198 WP_000772027.1 DUF957 domain-containing protein -
I02_RS05830 1202256..1203083 + 828 WP_001304477.1 DUF4942 domain-containing protein -
I02_RS05840 1203570..1204508 + 939 WP_000351287.1 glyoxylate/hydroxypyruvate reductase GhrA -
I02_RS05845 1204563..1205300 + 738 WP_000283664.1 zinc-binding phosphatase -
I02_RS05850 1205324..1205878 + 555 WP_001001909.1 molecular chaperone YcdY -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - csgG / csgF / csgE / csgD / csgB / csgA / csgC 1175900..1210979 35079


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 127 a.a.        Molecular weight: 14214.14 Da        Isoelectric Point: 6.4773

>T27509 WP_000854739.1 NC_017651:1201089-1201469 [Escherichia coli str. 'clone D i2']
MKTLPDTHVREASRCPSPVTIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SAGVPSQLINSIDILRARRATGLMTRDNYRTVNDITLGRHPEEAKQ

Download         Length: 381 bp

>T27509 NC_017651:1201089-1201469 [Escherichia coli str. 'clone D i2']
ATGAAAACATTACCTGACACACACGTACGGGAGGCATCGCGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAC
CCGACTGTTGGACCAGCATTACGGCCTCACACTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGGATTTCACTGTGTGACGCGGTGAACTTTCTCGTTGAAAAATACGCGCTGGTACGAACTGACCAGCCGGGATTC
AGCGCAGGAGTCCCGTCGCAGTTAATCAACAGCATCGATATTCTCCGGGCCCGCCGGGCAACCGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATGACATTACCCTGGGCAGGCATCCGGAGGAGGCGAAACAATGA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 13791.44 Da        Isoelectric Point: 4.7511

>AT27509 WP_001285482.1 NC_017651:1200668-1201042 [Escherichia coli str. 'clone D i2']
VSDTLHETNYPDDNNDRPWWGLPCTVTPCFGARLVQEGNQLHYLADRAGIRGQFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYARGLTCEADTLGSCGYVYMAVYPTLAPATTS

Download         Length: 375 bp

>AT27509 NC_017651:1200668-1201042 [Escherichia coli str. 'clone D i2']
GTGTCAGACACGCTCCATGAAACAAATTATCCCGACGACAACAACGACCGCCCCTGGTGGGGGCTACCCTGCACCGTGAC
GCCCTGTTTCGGGGCACGTCTGGTGCAGGAGGGCAATCAGTTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGGCAGT
TCAGCGACGCGGATGCATACCATCTGGACCAGGCTTTTCCACTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACGCTGTATGCCAGAGGGCTGACCTGCGAAGCCGACACCCTCGGCAGCTG
TGGTTACGTTTATATGGCTGTTTATCCGACACTGGCACCCGCAACCACCTCATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H2V687

Antitoxin

Source ID Structure
AlphaFold DB A0A0P7R0L9

References