Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) kacAT/DUF1778(antitoxin)
Location 1739160..1739957 Replicon chromosome
Accession NZ_CP120524
Organism Enterobacter roggenkampii strain 0-E

Toxin (Protein)


Gene name KacT Uniprot ID A0A155TD66
Locus tag P3S52_RS09515 Protein ID WP_032651255.1
Coordinates 1739436..1739957 (+) Length 174 a.a.

Antitoxin (Protein)


Gene name KacA Uniprot ID W7PG43
Locus tag P3S52_RS09510 Protein ID WP_008499829.1
Coordinates 1739160..1739429 (+) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P3S52_RS09480 (P3S52_09500) 1734783..1735226 - 444 WP_008499834.1 helix-turn-helix domain-containing protein -
P3S52_RS09485 (P3S52_09505) 1735379..1736620 + 1242 WP_032651252.1 bifunctional glucose-1-phosphatase/inositol phosphatase -
P3S52_RS09490 (P3S52_09510) 1736656..1736883 - 228 WP_008499832.1 YccJ family protein -
P3S52_RS09495 (P3S52_09515) 1736904..1737500 - 597 WP_008499831.1 NAD(P)H:quinone oxidoreductase -
P3S52_RS09500 (P3S52_09520) 1737892..1738062 + 171 WP_013097201.1 general stress protein -
P3S52_RS09505 (P3S52_09525) 1738181..1739098 + 918 WP_025912980.1 DMT family transporter -
P3S52_RS09510 (P3S52_09530) 1739160..1739429 + 270 WP_008499829.1 DUF1778 domain-containing protein Antitoxin
P3S52_RS09515 (P3S52_09535) 1739436..1739957 + 522 WP_032651255.1 GNAT family N-acetyltransferase Toxin
P3S52_RS09520 (P3S52_09540) 1740031..1741353 - 1323 WP_008499826.1 pyrimidine utilization transport protein G -
P3S52_RS09525 (P3S52_09545) 1741375..1741869 - 495 WP_008499825.1 pyrimidine utilization flavin reductase protein F -
P3S52_RS09530 (P3S52_09550) 1741879..1742469 - 591 WP_032651257.1 malonic semialdehyde reductase -
P3S52_RS09535 (P3S52_09555) 1742479..1743279 - 801 WP_021240807.1 pyrimidine utilization protein D -
P3S52_RS09540 (P3S52_09560) 1743287..1743673 - 387 WP_008499822.1 pyrimidine utilization protein C -
P3S52_RS09545 (P3S52_09565) 1743685..1744374 - 690 WP_028012657.1 pyrimidine utilization protein B -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Vibrio phage ICP1, Orf50

(8-86)


Sequences

Toxin        


Download         Length: 174 a.a.        Molecular weight: 19714.46 Da        Isoelectric Point: 7.0497

>T275089 WP_032651255.1 NZ_CP120524:1739436-1739957 [Enterobacter roggenkampii]
VDNLTIEMFSEGKDYDFRDFDCGEPSLNVFLTEHLVRQHNGRILRGYLLKDRDGPRVLGYYTLSGSCFEKAMLPSKTQQR
RIPYSNVPSVTLGRLAIHKDLQGLEWGTTLVTHAMRVVYLASQAVGVHGIFVDALNDQAKQFYLKQGFIPLTDENSHSLF
FPTKSIERLFEQA

Download         Length: 522 bp

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 10262.72 Da        Isoelectric Point: 5.8836

>AT275089 WP_008499829.1 NZ_CP120524:1739160-1739429 [Enterobacter roggenkampii]
MPALKKQRIDLRLTDEDKTMIEEAAAMTNQTITQFMVNSASERAAEVIEQHRRLVLNEASWNAVMDAIDNPPEPNERLKR
AAKRLRNME

Download         Length: 270 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A155TD66

Antitoxin

Source ID Structure
AlphaFold DB W7PG43

References