Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1096059..1096679 Replicon chromosome
Accession NZ_CP120524
Organism Enterobacter roggenkampii strain 0-E

Toxin (Protein)


Gene name Hha Uniprot ID A0A1H8SI38
Locus tag P3S52_RS06315 Protein ID WP_008499287.1
Coordinates 1096059..1096277 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID V3PBI9
Locus tag P3S52_RS06320 Protein ID WP_008499288.1
Coordinates 1096305..1096679 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P3S52_RS06285 (P3S52_06295) 1092072..1092332 + 261 WP_006176933.1 type B 50S ribosomal protein L31 -
P3S52_RS06290 (P3S52_06300) 1092335..1092475 + 141 WP_003859006.1 type B 50S ribosomal protein L36 -
P3S52_RS06295 (P3S52_06305) 1092472..1093182 - 711 WP_032656573.1 GNAT family protein -
P3S52_RS06300 (P3S52_06310) 1093284..1094744 + 1461 WP_032656575.1 PLP-dependent aminotransferase family protein -
P3S52_RS06305 (P3S52_06315) 1094716..1095183 - 468 WP_008499285.1 YlaC family protein -
P3S52_RS06310 (P3S52_06320) 1095301..1095852 - 552 WP_008499286.1 maltose O-acetyltransferase -
P3S52_RS06315 (P3S52_06325) 1096059..1096277 - 219 WP_008499287.1 HHA domain-containing protein Toxin
P3S52_RS06320 (P3S52_06330) 1096305..1096679 - 375 WP_008499288.1 Hha toxicity modulator TomB Antitoxin
P3S52_RS06325 (P3S52_06335) 1097188..1100334 - 3147 WP_200448353.1 multidrug efflux RND transporter permease subunit AcrB -
P3S52_RS06330 (P3S52_06340) 1100357..1101550 - 1194 WP_021241633.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-114)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8612.00 Da        Isoelectric Point: 8.9008

>T275088 WP_008499287.1 NZ_CP120524:c1096277-1096059 [Enterobacter roggenkampii]
MSDKPLTKIDYLMRLRRCQSIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFVR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14481.28 Da        Isoelectric Point: 4.8886

>AT275088 WP_008499288.1 NZ_CP120524:c1096679-1096305 [Enterobacter roggenkampii]
MDEYSPKRHDIAQLKFLCESLYHDCLANLDESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINAQDLQKWRKSGNRLFRCFVNVSRANPVSLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1H8SI38

Antitoxin

Source ID Structure
AlphaFold DB V3PBI9

References