Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 125719..126245 Replicon plasmid pER0-E1
Accession NZ_CP120521
Organism Enterobacter roggenkampii strain 0-E

Toxin (Protein)


Gene name relE Uniprot ID S1EXL1
Locus tag P3S52_RS00625 Protein ID WP_000323025.1
Coordinates 125719..126006 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID J5W3H0
Locus tag P3S52_RS00630 Protein ID WP_004196370.1
Coordinates 126006..126245 (-) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P3S52_RS00590 (P3S52_00590) 121296..121589 - 294 WP_057061548.1 hypothetical protein -
P3S52_RS00595 (P3S52_00595) 122280..122615 - 336 WP_045409790.1 hypothetical protein -
P3S52_RS00600 (P3S52_00600) 122659..123450 - 792 WP_045409787.1 N-6 DNA methylase -
P3S52_RS00605 (P3S52_00605) 123491..123691 - 201 WP_031494497.1 hypothetical protein -
P3S52_RS00610 (P3S52_00610) 123779..124240 - 462 WP_052672942.1 DUF1419 domain-containing protein -
P3S52_RS00615 (P3S52_00615) 124298..124613 - 316 Protein_122 hypothetical protein -
P3S52_RS00620 (P3S52_00620) 125493..125666 - 174 WP_236593106.1 DUF5431 family protein -
P3S52_RS00625 (P3S52_00625) 125719..126006 - 288 WP_000323025.1 type II toxin-antitoxin system mRNA interferase RelE Toxin
P3S52_RS00630 (P3S52_00630) 126006..126245 - 240 WP_004196370.1 type II toxin-antitoxin system antitoxin RelB Antitoxin
P3S52_RS00635 (P3S52_00635) 126270..126368 + 99 Protein_126 protein YdfV -
P3S52_RS00640 (P3S52_00640) 126496..126861 + 366 WP_009651956.1 hypothetical protein -
P3S52_RS00645 (P3S52_00645) 126905..127642 + 738 WP_008460272.1 HupE/UreJ family protein -
P3S52_RS00650 (P3S52_00650) 127656..128345 + 690 WP_004196322.1 hypothetical protein -
P3S52_RS00655 (P3S52_00655) 128376..129752 - 1377 WP_004196363.1 chromate efflux transporter -
P3S52_RS00660 (P3S52_00660) 129709..130686 - 978 WP_004196334.1 chromate resistance protein -
P3S52_RS00665 (P3S52_00665) 130716..130908 + 193 Protein_132 MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - mrkA / mrkB / mrkC / mrkD / mrkF / mrkJ 1..157085 157085


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-86)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(3-79)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11225.22 Da        Isoelectric Point: 10.1967

>T275085 WP_000323025.1 NZ_CP120521:c126006-125719 [Enterobacter roggenkampii]
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL

Download         Length: 288 bp

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 9018.43 Da        Isoelectric Point: 4.3894

>AT275085 WP_004196370.1 NZ_CP120521:c126245-126006 [Enterobacter roggenkampii]
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLCNPKPVRVTLDEL

Download         Length: 240 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4V7K
PDB 4V7J
PDB 4FXI
PDB 4FXE
PDB 2KC8
PDB 4FXH
PDB 2KC9

Antitoxin

Source ID Structure
AlphaFold DB A0A2J4QRH4

References