275084

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) spoIISABC/SpoIISA-SpoIISB
Location 1381760..1382676 Replicon chromosome
Accession NZ_CP120511
Organism Bacillus sp. B28

Toxin (Protein)


Gene name spoIISA Uniprot ID A0A7G7U9Y2
Locus tag P3L57_RS06950 Protein ID WP_024121091.1
Coordinates 1381930..1382676 (-) Length 249 a.a.

Antitoxin (Protein)


Gene name spoIISB Uniprot ID A0A7G7U9Y3
Locus tag P3L57_RS06945 Protein ID WP_024121090.1
Coordinates 1381760..1381930 (-) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P3L57_RS06905 (P3L57_06905) 1377128..1377400 + 273 WP_044156234.1 hypothetical protein -
P3L57_RS06910 (P3L57_06910) 1377403..1379370 + 1968 WP_069486429.1 pyocin knob domain-containing protein -
P3L57_RS06915 (P3L57_06915) 1379384..1379773 + 390 WP_059336104.1 hypothetical protein -
P3L57_RS06920 (P3L57_06920) 1379774..1379914 + 141 WP_059336103.1 XkdX family protein -
P3L57_RS06925 (P3L57_06925) 1380043..1380321 + 279 WP_059336102.1 hemolysin XhlA family protein -
P3L57_RS06930 (P3L57_06930) 1380333..1380596 + 264 WP_024121086.1 phage holin -
P3L57_RS06935 (P3L57_06935) 1380609..1381502 + 894 WP_059336101.1 N-acetylmuramoyl-L-alanine amidase -
P3L57_RS06940 (P3L57_06940) 1381539..1381676 - 138 WP_125825426.1 three component toxin-antitoxin-antitoxin system antitoxin SpoIISC -
P3L57_RS06945 (P3L57_06945) 1381760..1381930 - 171 WP_024121090.1 type II toxin-antitoxin system SpoIISB family antitoxin Antitoxin
P3L57_RS06950 (P3L57_06950) 1381930..1382676 - 747 WP_024121091.1 toxin-antitoxin-antitoxin system toxin SpoIISA Toxin
P3L57_RS06955 (P3L57_06955) 1382785..1383786 - 1002 WP_044156221.1 inorganic phosphate transporter -
P3L57_RS06960 (P3L57_06960) 1383799..1384416 - 618 WP_044156219.1 DUF47 domain-containing protein -
P3L57_RS06965 (P3L57_06965) 1384694..1386010 - 1317 WP_059336100.1 serine/threonine exchanger -
P3L57_RS06970 (P3L57_06970) 1386405..1387355 + 951 WP_069486430.1 ring-cleaving dioxygenase -
P3L57_RS06975 (P3L57_06975) 1387521..1387601 + 81 Protein_1310 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 1347597..1391118 43521


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin SpoIISA, type II toxin-antitoxin system

(3-238)

Antitoxin

Antitoxin SpoIISB

(1-56)


Sequences

Toxin        


Download         Length: 249 a.a.        Molecular weight: 29076.48 Da        Isoelectric Point: 4.4986

>T275084 WP_024121091.1 NZ_CP120511:c1382676-1381930 [Bacillus sp. B28]
MLLFFQIMVWCTMAALGLYVYATWRFEAKVKEKMSAIRKTWYLLFVLGAMIYWTYDPSSLFTNWERYVIVAVSFALIDAF
IFLSAYVKKLAGSELETDTREILEENNEMLHMYLDRLKTYQYLLKNEPIHVYYGSIEAYAEGIDKLLKTYADKMNLTASL
CHYSTQSDKDRLTEHMEDPADVQTRLDRKDVYYDQYGKVVLIPFTIETQSYVIKLTSDSIVTEFDYLLFTSLTSIYDLVL
PIEEEGEG

Download         Length: 747 bp

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6578.62 Da        Isoelectric Point: 10.9236

>AT275084 WP_024121090.1 NZ_CP120511:c1381930-1381760 [Bacillus sp. B28]
MENAFQNGCHPRAKKPFKILKKRSTTSVASYQVSPHTARIFKENERLIDEYKRKKA

Download         Length: 171 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7G7U9Y2

Antitoxin

Source ID Structure
AlphaFold DB A0A7G7U9Y3

References