Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 1370658..1371128 Replicon chromosome
Accession NZ_CP120426
Organism Staphylococcus epidermidis strain 25FSE01

Toxin (Protein)


Gene name TsaT Uniprot ID Q5HQS5
Locus tag P5W78_RS06385 Protein ID WP_001829569.1
Coordinates 1370658..1370846 (-) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID D4FNP2
Locus tag P5W78_RS06390 Protein ID WP_002438963.1
Coordinates 1370871..1371128 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P5W78_RS06355 1367139..1367339 + 201 WP_001829681.1 cold-shock protein -
P5W78_RS06360 1367960..1368184 - 225 WP_001829613.1 hypothetical protein -
P5W78_RS06365 1368208..1368492 - 285 WP_001829635.1 hypothetical protein -
P5W78_RS06370 1368591..1369337 - 747 WP_002438959.1 poly-gamma-glutamate hydrolase family protein -
P5W78_RS06375 1369621..1369854 + 234 WP_001829664.1 hypothetical protein -
P5W78_RS06380 1369914..1370468 - 555 WP_218085209.1 lipoprotein N-acylation protein LnsA -
P5W78_RS06385 1370658..1370846 - 189 WP_001829569.1 hypothetical protein Toxin
P5W78_RS06390 1370871..1371128 - 258 WP_002438963.1 hypothetical protein Antitoxin
P5W78_RS06395 1371537..1371740 + 204 WP_002438966.1 sterile alpha motif-like domain-containing protein -
P5W78_RS06400 1371732..1371968 - 237 WP_002457224.1 hypothetical protein -
P5W78_RS06405 1372182..1372769 + 588 WP_001829615.1 histidine phosphatase family protein -
P5W78_RS06410 1373040..1373540 - 501 WP_001829623.1 GNAT family N-acetyltransferase -
P5W78_RS06415 1373927..1374114 + 188 Protein_1242 hypothetical protein -
P5W78_RS06420 1374144..1374281 + 138 WP_162161215.1 hypothetical protein -
P5W78_RS06425 1374465..1374887 - 423 WP_002457221.1 organic hydroperoxide resistance protein -
P5W78_RS06430 1375048..1375764 + 717 WP_001831974.1 type I 3-dehydroquinate dehydratase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 1367139..1380156 13017
- flank IS/Tn - - 1374126..1374281 155


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7229.94 Da        Isoelectric Point: 9.7844

>T275080 WP_001829569.1 NZ_CP120426:c1370846-1370658 [Staphylococcus epidermidis]
MSLHFQILLWLSILFIIAGTILLVTMLKTKKEERKESYLGFTVIFLIFGFAILIYTFIFGIL

Download         Length: 189 bp

>T275080 NZ_CP120426:c1370846-1370658 [Staphylococcus epidermidis]
ATGAGCTTACATTTCCAAATTTTGCTGTGGCTTTCTATCTTATTTATCATCGCAGGAACGATATTATTGGTAACAATGCT
TAAAACTAAAAAAGAAGAACGAAAAGAATCTTATCTAGGCTTTACTGTAATTTTCTTAATCTTTGGTTTTGCCATCTTAA
TTTATACTTTTATATTCGGAATTTTATAA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 10014.05 Da        Isoelectric Point: 4.5440

>AT275080 WP_002438963.1 NZ_CP120426:c1371128-1370871 [Staphylococcus epidermidis]
MKLNKANIFNLIFTILFFSFNILITYNANIDYKLWLIPGLAICGFALFSSLTLVIIYSDLFSEILFFINIILALYYIYPI
FYEFV

Download         Length: 258 bp

>AT275080 NZ_CP120426:c1371128-1370871 [Staphylococcus epidermidis]
ATGAAATTAAACAAAGCAAATATATTCAATTTGATATTCACCATTTTATTTTTTTCATTTAACATTCTCATAACCTATAA
CGCAAATATAGATTATAAGTTATGGTTAATACCTGGTTTAGCAATTTGTGGTTTTGCTCTTTTTTCAAGCTTGACCTTAG
TAATTATCTATAGTGATTTATTCAGTGAAATATTATTTTTTATCAACATTATCTTAGCACTGTATTACATTTATCCGATT
TTTTATGAATTTGTCTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0N0LUH8

Antitoxin

Source ID Structure
AlphaFold DB A0A0U5IVM3

References