Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 23071..23580 Replicon chromosome
Accession NZ_CP120426
Organism Staphylococcus epidermidis strain 25FSE01

Toxin (Protein)


Gene name TsdT Uniprot ID Q5HMD5
Locus tag P5W78_RS00120 Protein ID WP_001829980.1
Coordinates 23071..23280 (-) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID Q5HMD4
Locus tag P5W78_RS00125 Protein ID WP_001829893.1
Coordinates 23287..23580 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P5W78_RS00100 18649..20004 - 1356 WP_001832734.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -
P5W78_RS00105 20016..21089 - 1074 WP_001832735.1 D-alanine--D-alanine ligase -
P5W78_RS00110 21480..22691 + 1212 WP_001829910.1 FtsW/RodA/SpoVE family cell cycle protein -
P5W78_RS00115 22791..22928 - 138 WP_001829949.1 Lmo0850 family protein -
P5W78_RS00120 23071..23280 - 210 WP_001829980.1 heavy-metal-associated domain-containing protein Toxin
P5W78_RS00125 23287..23580 - 294 WP_001829893.1 copper-sensing transcriptional repressor CsoR Antitoxin
P5W78_RS00130 23754..25237 + 1484 Protein_20 cardiolipin synthase -
P5W78_RS00135 25419..26072 + 654 WP_001829983.1 HD domain-containing protein -
P5W78_RS00140 26178..27050 - 873 WP_002458703.1 membrane protein insertase YidC -
P5W78_RS00145 27139..27777 - 639 WP_002505076.1 thiamine phosphate synthase -
P5W78_RS00150 27783..28571 - 789 WP_001829971.1 hydroxyethylthiazole kinase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Metal-sensitive transcriptional repressor

(4-95)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7987.24 Da        Isoelectric Point: 7.0080

>T275079 WP_001829980.1 NZ_CP120426:c23280-23071 [Staphylococcus epidermidis]
MKLKKGLINVSGIKTTEQAKQLKDHLSKMIGINSVDIDYQMNEIRVEFDTPANLNNIEKEIYDYGFRIL

Download         Length: 210 bp

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11070.65 Da        Isoelectric Point: 5.5778

>AT275079 WP_001829893.1 NZ_CP120426:c23580-23287 [Staphylococcus epidermidis]
MADMESAHHSEQIKTNLKSRLNRIEGQVRAINRMIDDDVYCDDVLTQIRATRSALNSVATKLLDHHMKGCIMEKINDGAQ
EEAMDELLVTFQKLIKD

Download         Length: 294 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2G7HWU1

Antitoxin

Source ID Structure
AlphaFold DB A0A0N1EPA7

References