Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 2203534..2204063 Replicon chromosome
Accession NZ_CP120425
Organism Staphylococcus epidermidis strain 25DSE01

Toxin (Protein)


Gene name mazF Uniprot ID Q5HME7
Locus tag P5W76_RS10535 Protein ID WP_001829891.1
Coordinates 2203701..2204063 (+) Length 121 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID Q5HME6
Locus tag P5W76_RS10530 Protein ID WP_001829931.1
Coordinates 2203534..2203704 (+) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P5W76_RS10505 2199359..2199838 + 480 WP_001829909.1 PH domain-containing protein -
P5W76_RS10510 2199831..2201336 + 1506 WP_001829976.1 PH domain-containing protein -
P5W76_RS10515 2201323..2201832 + 510 WP_001829888.1 PH domain-containing protein -
P5W76_RS10520 2201880..2202233 + 354 WP_001829915.1 holo-ACP synthase -
P5W76_RS10525 2202299..2203447 + 1149 WP_002468951.1 alanine racemase -
P5W76_RS10530 2203534..2203704 + 171 WP_001829931.1 type II toxin-antitoxin system antitoxin MazE Antitoxin
P5W76_RS10535 2203701..2204063 + 363 WP_001829891.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
P5W76_RS10540 2204409..2205410 + 1002 WP_001829902.1 PP2C family protein-serine/threonine phosphatase -
P5W76_RS10545 2205510..2205836 + 327 WP_001829952.1 anti-sigma factor antagonist -
P5W76_RS10550 2205838..2206317 + 480 WP_002484520.1 anti-sigma B factor RsbW -
P5W76_RS10555 2206292..2207062 + 771 WP_002468952.1 RNA polymerase sigma factor SigB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(1-112)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 121 a.a.        Molecular weight: 13497.65 Da        Isoelectric Point: 9.9522

>T275076 WP_001829891.1 NZ_CP120425:2203701-2204063 [Staphylococcus epidermidis]
MIRRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKKKYKLDKDSVILLEQIR
TLDKKRLKEKLTFLSESKMIEVDNALDISLGLNNFDHHKS

Download         Length: 363 bp

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6289.92 Da        Isoelectric Point: 4.1920

>AT275076 WP_001829931.1 NZ_CP120425:2203534-2203704 [Staphylococcus epidermidis]
MLSFNQNRNHSLEQSLKEGYAQMADLNLSLATEAFPIECEACDCNESHLISNSKNE

Download         Length: 171 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2G7HWR0

Antitoxin

Source ID Structure
AlphaFold DB A0A0N1EF65

References