Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 954118..954627 Replicon chromosome
Accession NZ_CP120424
Organism Staphylococcus epidermidis strain 32FSE06

Toxin (Protein)


Gene name TsdT Uniprot ID Q5HMD5
Locus tag P5W77_RS04405 Protein ID WP_001829980.1
Coordinates 954418..954627 (+) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID Q5HMD4
Locus tag P5W77_RS04400 Protein ID WP_001829893.1
Coordinates 954118..954411 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P5W77_RS04375 949126..949914 + 789 WP_001829971.1 hydroxyethylthiazole kinase -
P5W77_RS04380 949920..950558 + 639 WP_002505076.1 thiamine phosphate synthase -
P5W77_RS04385 950647..951519 + 873 WP_002458703.1 membrane protein insertase YidC -
P5W77_RS04390 951625..952278 - 654 WP_001829983.1 HD domain-containing protein -
P5W77_RS04395 952460..953944 - 1485 WP_002457116.1 cardiolipin synthase -
P5W77_RS04400 954118..954411 + 294 WP_001829893.1 copper-sensing transcriptional repressor CsoR Antitoxin
P5W77_RS04405 954418..954627 + 210 WP_001829980.1 heavy-metal-associated domain-containing protein Toxin
P5W77_RS04410 954770..954907 + 138 WP_001829949.1 Lmo0850 family protein -
P5W77_RS04415 955006..956217 - 1212 WP_002486299.1 FtsW/RodA/SpoVE family cell cycle protein -
P5W77_RS04420 956608..957681 + 1074 WP_002468311.1 D-alanine--D-alanine ligase -
P5W77_RS04425 957693..959048 + 1356 WP_002457113.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Metal-sensitive transcriptional repressor

(4-95)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7987.24 Da        Isoelectric Point: 7.0080

>T275070 WP_001829980.1 NZ_CP120424:954418-954627 [Staphylococcus epidermidis]
MKLKKGLINVSGIKTTEQAKQLKDHLSKMIGINSVDIDYQMNEIRVEFDTPANLNNIEKEIYDYGFRIL

Download         Length: 210 bp

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11070.65 Da        Isoelectric Point: 5.5778

>AT275070 WP_001829893.1 NZ_CP120424:954118-954411 [Staphylococcus epidermidis]
MADMESAHHSEQIKTNLKSRLNRIEGQVRAINRMIDDDVYCDDVLTQIRATRSALNSVATKLLDHHMKGCIMEKINDGAQ
EEAMDELLVTFQKLIKD

Download         Length: 294 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2G7HWU1

Antitoxin

Source ID Structure
AlphaFold DB A0A0N1EPA7

References