Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 11872..12401 Replicon chromosome
Accession NZ_CP120423
Organism Staphylococcus epidermidis strain 41DSE01

Toxin (Protein)


Gene name mazF Uniprot ID Q5HME7
Locus tag P5W75_RS00060 Protein ID WP_001829891.1
Coordinates 11872..12234 (-) Length 121 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID Q5HME6
Locus tag P5W75_RS00065 Protein ID WP_001829931.1
Coordinates 12231..12401 (-) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P5W75_RS00040 8874..9644 - 771 WP_002468952.1 RNA polymerase sigma factor SigB -
P5W75_RS00045 9619..10098 - 480 WP_002484520.1 anti-sigma B factor RsbW -
P5W75_RS00050 10100..10426 - 327 WP_001829952.1 anti-sigma factor antagonist -
P5W75_RS00055 10526..11527 - 1002 WP_001829902.1 PP2C family protein-serine/threonine phosphatase -
P5W75_RS00060 11872..12234 - 363 WP_001829891.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
P5W75_RS00065 12231..12401 - 171 WP_001829931.1 type II toxin-antitoxin system antitoxin MazE Antitoxin
P5W75_RS00070 12488..13636 - 1149 WP_218085223.1 alanine racemase -
P5W75_RS00075 13702..14055 - 354 WP_001829915.1 holo-ACP synthase -
P5W75_RS00080 14103..14612 - 510 WP_001829888.1 PH domain-containing protein -
P5W75_RS00085 14599..16104 - 1506 WP_001829976.1 PH domain-containing protein -
P5W75_RS00090 16097..16576 - 480 WP_001829909.1 PH domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(1-112)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 121 a.a.        Molecular weight: 13497.65 Da        Isoelectric Point: 9.9522

>T275066 WP_001829891.1 NZ_CP120423:c12234-11872 [Staphylococcus epidermidis]
MIRRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKKKYKLDKDSVILLEQIR
TLDKKRLKEKLTFLSESKMIEVDNALDISLGLNNFDHHKS

Download         Length: 363 bp

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6289.92 Da        Isoelectric Point: 4.1920

>AT275066 WP_001829931.1 NZ_CP120423:c12401-12231 [Staphylococcus epidermidis]
MLSFNQNRNHSLEQSLKEGYAQMADLNLSLATEAFPIECEACDCNESHLISNSKNE

Download         Length: 171 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2G7HWR0

Antitoxin

Source ID Structure
AlphaFold DB A0A0N1EF65

References