Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 4250117..4250898 Replicon chromosome
Accession NZ_CP120399
Organism Salmonella enterica subsp. enterica serovar Typhi strain 314-2017_CO_03

Toxin (Protein)


Gene name TacT2 Uniprot ID Q8Z1M4
Locus tag PVA79_RS21005 Protein ID WP_000626103.1
Coordinates 4250117..4250608 (-) Length 164 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID Q8Z1M5
Locus tag PVA79_RS21010 Protein ID WP_001110456.1
Coordinates 4250605..4250898 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PVA79_RS20985 (PVA79_20980) 4245884..4247248 - 1365 WP_000018529.1 SPI-7-type island replicative DNA helicase -
PVA79_RS20990 (PVA79_20985) 4247245..4248279 - 1035 WP_001195363.1 ParA family protein -
PVA79_RS20995 (PVA79_20995) 4248947..4249024 + 78 Protein_4112 porin family protein -
PVA79_RS21000 (PVA79_21000) 4249124..4249876 + 753 WP_001785756.1 non-specific acid phosphatase -
PVA79_RS21005 (PVA79_21005) 4250117..4250608 - 492 WP_000626103.1 GNAT family N-acetyltransferase Toxin
PVA79_RS21010 (PVA79_21010) 4250605..4250898 - 294 WP_001110456.1 DUF1778 domain-containing protein Antitoxin
PVA79_RS21015 (PVA79_21015) 4251215..4251437 + 223 Protein_4116 hypothetical protein -
PVA79_RS21020 (PVA79_21020) 4251703..4252578 + 876 WP_000921674.1 AraC family transcriptional regulator -
PVA79_RS21025 (PVA79_21025) 4252575..4252862 + 288 WP_001269916.1 transcriptional regulator RtsB -
PVA79_RS21030 (PVA79_21030) 4252885..4253101 + 217 Protein_4119 hypothetical protein -
PVA79_RS21035 (PVA79_21035) 4253109..4253453 + 345 WP_100680417.1 Ig-like domain-containing protein -
PVA79_RS21040 (PVA79_21040) 4253740..4254645 - 906 WP_001268195.1 YjiK family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(85-145)

Antitoxin

Vibrio phage ICP1, Orf50

(14-88)


Sequences

Toxin        


Download         Length: 164 a.a.        Molecular weight: 17675.47 Da        Isoelectric Point: 7.2652

>T275062 WP_000626103.1 NZ_CP120399:c4250608-4250117 [Salmonella enterica subsp. enterica serovar Typhi]
MISTPEPLHAGHILTPFCCGVDSIDNWLKQRAMKNQTTGASRTFVCCGSDSNVLAYYSLASSAVTTNTSPGRFRRNMPDP
IPVVVLGRLAVDKSLHGQGVARALVRDAGLRVIQVAETIGIRGMLVHALSDEAREFYQWVGFVPSPMDPMMLMVTLGDLV
ESV

Download         Length: 492 bp

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11005.67 Da        Isoelectric Point: 8.6141

>AT275062 WP_001110456.1 NZ_CP120399:c4250898-4250605 [Salmonella enterica subsp. enterica serovar Typhi]
MPAANSMAMKRETLNLRIKPAERDLIDRAAKARGKNRTDFVLEAARAAAEEVLIEQRIIMADPEAYQEFLVRLDQTPSPN
AALRKTMQTPAPWEQEK

Download         Length: 294 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A718CB38

Antitoxin

Source ID Structure
AlphaFold DB A0A716NSU2

References