Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3327985..3328605 Replicon chromosome
Accession NZ_CP120399
Organism Salmonella enterica subsp. enterica serovar Typhi strain 314-2017_CO_03

Toxin (Protein)


Gene name Hha Uniprot ID V1H8E6
Locus tag PVA79_RS16500 Protein ID WP_001280991.1
Coordinates 3328387..3328605 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID V1H4V6
Locus tag PVA79_RS16495 Protein ID WP_000344807.1
Coordinates 3327985..3328359 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PVA79_RS16485 (PVA79_16485) 3323124..3324317 + 1194 WP_001039199.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
PVA79_RS16490 (PVA79_16490) 3324340..3327489 + 3150 WP_001132507.1 efflux RND transporter permease AcrB -
PVA79_RS16495 (PVA79_16495) 3327985..3328359 + 375 WP_000344807.1 Hha toxicity modulator TomB Antitoxin
PVA79_RS16500 (PVA79_16500) 3328387..3328605 + 219 WP_001280991.1 HHA domain-containing protein Toxin
PVA79_RS16505 (PVA79_16505) 3328784..3329335 + 552 WP_001278793.1 maltose O-acetyltransferase -
PVA79_RS16510 (PVA79_16510) 3329453..3329923 + 471 WP_000136183.1 YlaC family protein -
PVA79_RS16515 (PVA79_16515) 3329979..3330119 - 141 WP_001197749.1 type B 50S ribosomal protein L36 -
PVA79_RS16520 (PVA79_16520) 3330125..3330385 - 261 WP_000801415.1 type B 50S ribosomal protein L31 -
PVA79_RS16525 (PVA79_16525) 3330610..3332160 + 1551 WP_000213129.1 EAL domain-containing protein -
PVA79_RS16535 (PVA79_16535) 3332391..3332780 + 390 WP_000961285.1 MGMT family protein -
PVA79_RS16540 (PVA79_16540) 3332813..3333382 - 570 WP_000779802.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8613.97 Da        Isoelectric Point: 8.9008

>T275058 WP_001280991.1 NZ_CP120399:3328387-3328605 [Salmonella enterica subsp. enterica serovar Typhi]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14453.27 Da        Isoelectric Point: 5.1444

>AT275058 WP_000344807.1 NZ_CP120399:3327985-3328359 [Salmonella enterica subsp. enterica serovar Typhi]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYNEDNKLIAQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4ICG

Antitoxin

Source ID Structure
AlphaFold DB A0A5I5FGI0

References