Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 204803..205563 Replicon chromosome
Accession NZ_CP120399
Organism Salmonella enterica subsp. enterica serovar Typhi strain 314-2017_CO_03

Toxin (Protein)


Gene name tacT Uniprot ID Q8Z2B1
Locus tag PVA79_RS00960 Protein ID WP_000533908.1
Coordinates 205078..205563 (+) Length 162 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID Q8Z2B2
Locus tag PVA79_RS00955 Protein ID WP_000965889.1
Coordinates 204803..205090 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PVA79_RS00935 (PVA79_00935) 200208..201119 + 912 WP_001168555.1 glycine--tRNA ligase subunit alpha -
PVA79_RS00940 (PVA79_00940) 201129..203198 + 2070 WP_001291805.1 glycine--tRNA ligase subunit beta -
PVA79_RS00945 (PVA79_00945) 203588..204016 + 429 Protein_187 IS3 family transposase -
PVA79_RS00950 (PVA79_00950) 204158..204625 + 468 WP_000702452.1 GNAT family N-acetyltransferase -
PVA79_RS00955 (PVA79_00955) 204803..205090 + 288 WP_000965889.1 DUF1778 domain-containing protein Antitoxin
PVA79_RS00960 (PVA79_00960) 205078..205563 + 486 WP_000533908.1 GNAT family N-acetyltransferase Toxin
PVA79_RS00965 (PVA79_00965) 205934..206473 - 540 WP_000047148.1 copper-binding periplasmic metallochaperone CueP -
PVA79_RS00970 (PVA79_00970) 206649..206861 - 213 WP_000014594.1 RNA chaperone/antiterminator CspA -
PVA79_RS00975 (PVA79_00975) 207152..207439 - 288 Protein_193 HTH-type transcriptional regulator -
PVA79_RS00980 (PVA79_00980) 207878..208588 + 711 WP_000190524.1 DUF3053 domain-containing protein -
PVA79_RS00985 (PVA79_00985) 208638..209612 - 975 WP_000804690.1 glyoxylate/hydroxypyruvate reductase GhrB -
PVA79_RS00990 (PVA79_00990) 209831..210493 - 663 WP_000747548.1 OmpA family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(31-152)

Antitoxin

Vibrio phage ICP1, Orf50

(13-89)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17689.38 Da        Isoelectric Point: 9.8719

>T275050 WP_000533908.1 NZ_CP120399:205078-205563 [Salmonella enterica subsp. enterica serovar Typhi]
VGRVTAPEPLSAFHQVAEFVSGEAVLDDWLKQKGLKNQALGAARTFVVCKKDTKQVAGFYSLATGSVNHTEATGNLRRNM
PDPIPVIILARLAVDLSFHGKGLGADLLHDAVLRCYRVAENIGVRAIMVHALTEDAKNFYIHHGFKSSQTQQRTLFLRLP
Q

Download         Length: 486 bp

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10964.59 Da        Isoelectric Point: 4.6811

>AT275050 WP_000965889.1 NZ_CP120399:204803-205090 [Salmonella enterica subsp. enterica serovar Typhi]
MLYKGCLMKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILETACRAAENVILDRRVFNFNDEQYEEFINLLDAPVADD
PVIEKLLARKPQWDV

Download         Length: 288 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A714MHS9

Antitoxin

Source ID Structure
AlphaFold DB A0A752RW74

References