Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | tacAT/DUF1778(antitoxin) |
| Location | 4245826..4246607 | Replicon | chromosome |
| Accession | NZ_CP120398 | ||
| Organism | Salmonella enterica subsp. enterica serovar Typhi strain 424-2019_CI | ||
Toxin (Protein)
| Gene name | TacT2 | Uniprot ID | Q8Z1M4 |
| Locus tag | PVA85_RS21040 | Protein ID | WP_000626103.1 |
| Coordinates | 4245826..4246317 (-) | Length | 164 a.a. |
Antitoxin (Protein)
| Gene name | TacA2 | Uniprot ID | Q8Z1M5 |
| Locus tag | PVA85_RS21045 | Protein ID | WP_001110456.1 |
| Coordinates | 4246314..4246607 (-) | Length | 98 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| PVA85_RS21020 (PVA85_21015) | 4241593..4242957 | - | 1365 | WP_000018529.1 | SPI-7-type island replicative DNA helicase | - |
| PVA85_RS21025 (PVA85_21020) | 4242954..4243988 | - | 1035 | WP_001195363.1 | ParA family protein | - |
| PVA85_RS21030 (PVA85_21030) | 4244656..4244733 | + | 78 | Protein_4123 | porin family protein | - |
| PVA85_RS21035 (PVA85_21035) | 4244833..4245585 | + | 753 | WP_001785756.1 | non-specific acid phosphatase | - |
| PVA85_RS21040 (PVA85_21040) | 4245826..4246317 | - | 492 | WP_000626103.1 | GNAT family N-acetyltransferase | Toxin |
| PVA85_RS21045 (PVA85_21045) | 4246314..4246607 | - | 294 | WP_001110456.1 | DUF1778 domain-containing protein | Antitoxin |
| PVA85_RS21050 (PVA85_21050) | 4246924..4247146 | + | 223 | Protein_4127 | hypothetical protein | - |
| PVA85_RS21055 (PVA85_21055) | 4247412..4248287 | + | 876 | WP_000921674.1 | AraC family transcriptional regulator | - |
| PVA85_RS21060 (PVA85_21060) | 4248284..4248571 | + | 288 | WP_001269916.1 | transcriptional regulator RtsB | - |
| PVA85_RS21065 (PVA85_21065) | 4248594..4248810 | + | 217 | Protein_4130 | hypothetical protein | - |
| PVA85_RS21070 (PVA85_21070) | 4248818..4249162 | + | 345 | WP_100680417.1 | Ig-like domain-containing protein | - |
| PVA85_RS21075 (PVA85_21075) | 4249449..4250354 | - | 906 | WP_001268195.1 | YjiK family protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 164 a.a. Molecular weight: 17675.47 Da Isoelectric Point: 7.2652
>T275047 WP_000626103.1 NZ_CP120398:c4246317-4245826 [Salmonella enterica subsp. enterica serovar Typhi]
MISTPEPLHAGHILTPFCCGVDSIDNWLKQRAMKNQTTGASRTFVCCGSDSNVLAYYSLASSAVTTNTSPGRFRRNMPDP
IPVVVLGRLAVDKSLHGQGVARALVRDAGLRVIQVAETIGIRGMLVHALSDEAREFYQWVGFVPSPMDPMMLMVTLGDLV
ESV
MISTPEPLHAGHILTPFCCGVDSIDNWLKQRAMKNQTTGASRTFVCCGSDSNVLAYYSLASSAVTTNTSPGRFRRNMPDP
IPVVVLGRLAVDKSLHGQGVARALVRDAGLRVIQVAETIGIRGMLVHALSDEAREFYQWVGFVPSPMDPMMLMVTLGDLV
ESV
Download Length: 492 bp
Antitoxin
Download Length: 98 a.a. Molecular weight: 11005.67 Da Isoelectric Point: 8.6141
>AT275047 WP_001110456.1 NZ_CP120398:c4246607-4246314 [Salmonella enterica subsp. enterica serovar Typhi]
MPAANSMAMKRETLNLRIKPAERDLIDRAAKARGKNRTDFVLEAARAAAEEVLIEQRIIMADPEAYQEFLVRLDQTPSPN
AALRKTMQTPAPWEQEK
MPAANSMAMKRETLNLRIKPAERDLIDRAAKARGKNRTDFVLEAARAAAEEVLIEQRIIMADPEAYQEFLVRLDQTPSPN
AALRKTMQTPAPWEQEK
Download Length: 294 bp
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A718CB38 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A716NSU2 |