Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | tacAT/DUF1778(antitoxin) |
| Location | 4123424..4124202 | Replicon | chromosome |
| Accession | NZ_CP120398 | ||
| Organism | Salmonella enterica subsp. enterica serovar Typhi strain 424-2019_CI | ||
Toxin (Protein)
| Gene name | TacT2 | Uniprot ID | Q8Z1C2 |
| Locus tag | PVA85_RS20340 | Protein ID | WP_000622308.1 |
| Coordinates | 4123424..4123912 (-) | Length | 163 a.a. |
Antitoxin (Protein)
| Gene name | TacA2 | Uniprot ID | Q8Z1C3 |
| Locus tag | PVA85_RS20345 | Protein ID | WP_001143724.1 |
| Coordinates | 4123909..4124202 (-) | Length | 98 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| PVA85_RS20325 (PVA85_20320) | 4119870..4122155 | + | 2286 | WP_010989300.1 | hypothetical protein | - |
| PVA85_RS20330 (PVA85_20325) | 4122459..4122710 | + | 252 | WP_024131240.1 | hypothetical protein | - |
| PVA85_RS20335 (PVA85_20330) | 4122792..4123244 | + | 453 | WP_000434168.1 | hypothetical protein | - |
| PVA85_RS20340 (PVA85_20335) | 4123424..4123912 | - | 489 | WP_000622308.1 | GNAT family N-acetyltransferase | Toxin |
| PVA85_RS20345 (PVA85_20340) | 4123909..4124202 | - | 294 | WP_001143724.1 | DUF1778 domain-containing protein | Antitoxin |
| PVA85_RS20350 (PVA85_20345) | 4124629..4125642 | - | 1014 | WP_000449622.1 | site-specific integrase | - |
| PVA85_RS20355 (PVA85_20350) | 4125806..4127395 | - | 1590 | WP_000488995.1 | TraI domain-containing protein | - |
| PVA85_RS20360 (PVA85_20355) | 4127379..4128890 | - | 1512 | WP_001120833.1 | UvrD-helicase domain-containing protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Integrative and Conjugative Element | - | tviB / tviC / tviD / tviE / vexA / vexB / vexC / vexD / vexE / sopE2 | 4111207..4244123 | 132916 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 163 a.a. Molecular weight: 17538.36 Da Isoelectric Point: 7.3252
>T275046 WP_000622308.1 NZ_CP120398:c4123912-4123424 [Salmonella enterica subsp. enterica serovar Typhi]
MISAPEPLHAGHILTPFCCGVDSMDNWLKQRAMKNQVTGASRTFVCCGSDSDVLAYYSLASSAVTTNTAPGRFRRNMPDP
IPVVVLGRLAVDRSLHGQGVGRALVRDAGLRVIQVAETIGIRGMLVHALSDEAREFYLRVGFEPSPMDPMMLMVTLGDLV
HA
MISAPEPLHAGHILTPFCCGVDSMDNWLKQRAMKNQVTGASRTFVCCGSDSDVLAYYSLASSAVTTNTAPGRFRRNMPDP
IPVVVLGRLAVDRSLHGQGVGRALVRDAGLRVIQVAETIGIRGMLVHALSDEAREFYLRVGFEPSPMDPMMLMVTLGDLV
HA
Download Length: 489 bp
Antitoxin
Download Length: 98 a.a. Molecular weight: 10906.59 Da Isoelectric Point: 6.3493
>AT275046 WP_001143724.1 NZ_CP120398:c4124202-4123909 [Salmonella enterica subsp. enterica serovar Typhi]
MPVANSMAMKRETLNLRIKPAERDLIDRAAKARGKNCTDFVLEAARAAAEEALIEQRIIMADPEAYQAFLIRLDQAPAPN
DALRKTMQTPAPWEQEK
MPVANSMAMKRETLNLRIKPAERDLIDRAAKARGKNCTDFVLEAARAAAEEALIEQRIIMADPEAYQAFLIRLDQAPAPN
DALRKTMQTPAPWEQEK
Download Length: 294 bp
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A716G941 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A716D9M3 |