Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) shpAB/BrnT-BrnA
Location 3903092..3903668 Replicon chromosome
Accession NZ_CP120398
Organism Salmonella enterica subsp. enterica serovar Typhi strain 424-2019_CI

Toxin (Protein)


Gene name shpA Uniprot ID M7RG88
Locus tag PVA85_RS19240 Protein ID WP_001131963.1
Coordinates 3903381..3903668 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name shpB Uniprot ID B5R9R5
Locus tag PVA85_RS19235 Protein ID WP_000063142.1
Coordinates 3903092..3903394 (-) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PVA85_RS19220 (PVA85_19220) 3899602..3901752 + 2151 WP_000379928.1 pyruvate/proton symporter BtsT -
PVA85_RS19225 (PVA85_19225) 3901847..3902050 + 204 WP_000460616.1 YbdD/YjiX family protein -
PVA85_RS19230 (PVA85_19230) 3902061..3903017 + 957 WP_000187846.1 GTPase -
PVA85_RS19235 (PVA85_19235) 3903092..3903394 - 303 WP_000063142.1 BrnA antitoxin family protein Antitoxin
PVA85_RS19240 (PVA85_19240) 3903381..3903668 - 288 WP_001131963.1 BrnT family toxin Toxin
PVA85_RS19245 (PVA85_19245) 3903921..3904835 - 915 WP_000290515.1 restriction endonuclease -
PVA85_RS19250 (PVA85_19250) 3905033..3908542 + 3510 WP_001043493.1 type I restriction-modification system endonuclease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Ribonuclease toxin, BrnT, of type II toxin-antitoxin system

(7-88)

Antitoxin

BrnA antitoxin of type II toxin-antitoxin system

(37-93)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11294.80 Da        Isoelectric Point: 9.5894

>T275044 WP_001131963.1 NZ_CP120398:c3903668-3903381 [Salmonella enterica subsp. enterica serovar Typhi]
MPMEFEWDANKAKSNLRKHGVRFEDAVLVFDDPRHLSRQERYENGEYRWQTLGLVHGIVVILVAHSVRFESGFEVIRIIS
ARKADRKERNRYEHG

Download         Length: 288 bp

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11373.96 Da        Isoelectric Point: 10.1293

>AT275044 WP_000063142.1 NZ_CP120398:c3903394-3903092 [Salmonella enterica subsp. enterica serovar Typhi]
MSMVKHKRGNASALSAQHEAELKALAKKSDDEIDYSDIPASEDGQWSEAVRGKFFRPLKTQASVRIDADVMEWLKRPGKG
YQTRLNAILREAMLREQNKK

Download         Length: 303 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7VD7

Antitoxin

Source ID Structure
PDB 7VD7
AlphaFold DB A0A4D6PB01

References