Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 836231..836856 Replicon chromosome
Accession NZ_CP120398
Organism Salmonella enterica subsp. enterica serovar Typhi strain 424-2019_CI

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag PVA85_RS04105 Protein ID WP_000911334.1
Coordinates 836458..836856 (+) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID M7S3S8
Locus tag PVA85_RS04100 Protein ID WP_000557549.1
Coordinates 836231..836458 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PVA85_RS04070 (PVA85_04070) 831402..832121 + 720 WP_000082599.1 Rha family transcriptional regulator -
PVA85_RS04075 (PVA85_04075) 832125..832328 + 204 WP_000184036.1 hypothetical protein -
PVA85_RS04080 (PVA85_04080) 832411..832866 + 456 WP_223229661.1 hypothetical protein -
PVA85_RS04085 (PVA85_04085) 832968..834089 + 1122 WP_000028980.1 hypothetical protein -
PVA85_RS04090 (PVA85_04090) 834722..835528 - 807 WP_077905073.1 DUF1460 domain-containing protein -
PVA85_RS04095 (PVA85_04095) 835803..836054 - 252 WP_001540858.1 hypothetical protein -
PVA85_RS04100 (PVA85_04100) 836231..836458 + 228 WP_000557549.1 toxin-antitoxin system antitoxin VapB Antitoxin
PVA85_RS04105 (PVA85_04105) 836458..836856 + 399 WP_000911334.1 tRNA(fMet)-specific endonuclease VapC Toxin
PVA85_RS04110 (PVA85_04110) 837663..838199 + 537 WP_001038500.1 STM3031 family outer membrane protein -
PVA85_RS04115 (PVA85_04115) 838246..838878 + 633 WP_000835268.1 YfdX family protein -
PVA85_RS04120 (PVA85_04120) 839597..840178 + 582 WP_001244646.1 fimbrial protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 816200..846761 30561


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-123)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 15091.44 Da        Isoelectric Point: 7.7785

>T275037 WP_000911334.1 NZ_CP120398:836458-836856 [Salmonella enterica subsp. enterica serovar Typhi]
MLKFMLDTNTCIFTIKNKPEHIRERFNLNTSRMCISSITLMELIYGAEKSLAPERNFAVVEGFISRLEVLDYDTQAAIHT
GQIRTELARKGTPVGSYDQMIAGHARSRGLVVVTNNLREFERIPGIRIEDWC

Download         Length: 399 bp

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8514.51 Da        Isoelectric Point: 5.0210

>AT275037 WP_000557549.1 NZ_CP120398:836231-836458 [Salmonella enterica subsp. enterica serovar Typhi]
MHTTLFFSNRTQAVRLPKSISFPEDVKHVEIIAVGRSRIITPVGESWDSWFDGEGASTDFMSTREQPAVQEREGF

Download         Length: 228 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
PDB 6IFM
AlphaFold DB A0A3V2Y5V5

References