Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 805446..806094 Replicon chromosome
Accession NZ_CP120398
Organism Salmonella enterica subsp. enterica serovar Typhi strain 424-2019_CI

Toxin (Protein)


Gene name cptA Uniprot ID A0A715BCB4
Locus tag PVA85_RS03915 Protein ID WP_000244762.1
Coordinates 805693..806094 (+) Length 134 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S5MU13
Locus tag PVA85_RS03910 Protein ID WP_000351186.1
Coordinates 805446..805712 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PVA85_RS03890 (PVA85_03890) 801374..802807 - 1434 WP_001230148.1 6-phospho-beta-glucosidase BglA -
PVA85_RS03895 (PVA85_03895) 802966..803277 + 312 WP_001182971.1 N(4)-acetylcytidine aminohydrolase -
PVA85_RS03900 (PVA85_03900) 803441..804100 + 660 WP_000250289.1 hemolysin III family protein -
PVA85_RS03905 (PVA85_03905) 804216..805196 - 981 WP_000874170.1 tRNA-modifying protein YgfZ -
PVA85_RS03910 (PVA85_03910) 805446..805712 + 267 WP_000351186.1 FAD assembly factor SdhE Antitoxin
PVA85_RS03915 (PVA85_03915) 805693..806094 + 402 WP_000244762.1 protein YgfX Toxin
PVA85_RS03920 (PVA85_03920) 806159..806680 - 522 WP_001055885.1 flavodoxin FldB -
PVA85_RS03925 (PVA85_03925) 806793..807689 + 897 WP_000434302.1 site-specific tyrosine recombinase XerD -
PVA85_RS03930 (PVA85_03930) 807713..808426 + 714 WP_000745614.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
PVA85_RS03935 (PVA85_03935) 808432..810165 + 1734 WP_000813396.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 134 a.a.        Molecular weight: 15773.75 Da        Isoelectric Point: 10.7537

>T275036 WP_000244762.1 NZ_CP120398:805693-806094 [Salmonella enterica subsp. enterica serovar Typhi]
VVLWQSDLRVSWRAQWISLLLHGLVAAVILLMPWPLSYTPLWMILLSLVVFDCVRSQRRINTCQGEIKLLMDGRLRWQGQ
DWTLLRPPWLLKSGMVLRLRAESGRHQHLWLAADSMEEAEWRELRRILLQQPI

Download         Length: 402 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10550.05 Da        Isoelectric Point: 6.0783

>AT275036 WP_000351186.1 NZ_CP120398:805446-805712 [Salmonella enterica subsp. enterica serovar Typhi]
MDIHNKARIHWACRRGMRELDISIMPFFEHEYDSLSDEEKRIFVRLLQSDDPDLFNWLMNHGKPADAELEQMVRLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A715BCB4

Antitoxin

Source ID Structure
AlphaFold DB A0A5I0YWH4

References