Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 3964721..3965237 Replicon chromosome
Accession NZ_CP120397
Organism Salmonella enterica subsp. enterica serovar Typhi strain 1521-2017_CI

Toxin (Protein)


Gene name relE Uniprot ID C0Q7A9
Locus tag PVA76_RS19445 Protein ID WP_000220578.1
Coordinates 3964721..3965005 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID V7ISI8
Locus tag PVA76_RS19450 Protein ID WP_000212724.1
Coordinates 3964995..3965237 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PVA76_RS19430 (PVA76_19425) 3959933..3961585 + 1653 WP_000155051.1 alpha,alpha-phosphotrehalase -
PVA76_RS19435 (PVA76_19430) 3961994..3964132 + 2139 WP_000187820.1 anaerobic ribonucleoside-triphosphate reductase -
PVA76_RS19440 (PVA76_19435) 3964253..3964717 + 465 WP_001268860.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
PVA76_RS19445 (PVA76_19440) 3964721..3965005 - 285 WP_000220578.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
PVA76_RS19450 (PVA76_19445) 3964995..3965237 - 243 WP_000212724.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
PVA76_RS19455 (PVA76_19450) 3965315..3967228 - 1914 WP_001212152.1 BglG family transcription antiterminator -
PVA76_RS19460 (PVA76_19455) 3967245..3967985 - 741 WP_000779260.1 KDGP aldolase family protein -
PVA76_RS19465 (PVA76_19460) 3967982..3969100 - 1119 WP_001139189.1 DgaE family pyridoxal phosphate-dependent ammonia lyase -
PVA76_RS19470 (PVA76_19465) 3969084..3970217 - 1134 WP_000459938.1 amidohydrolase/deacetylase family metallohydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 10854.67 Da        Isoelectric Point: 10.0482

>T275031 WP_000220578.1 NZ_CP120397:c3965005-3964721 [Salmonella enterica subsp. enterica serovar Typhi]
MTYELEFDPRALKEWHKLGDTVKAQLKKKLADVLLNPRIDSARLNGLPDCYKIKLKSSGYRLVYQVRDDVVIVFVVAVGK
REHSAVYHDANKRL

Download         Length: 285 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8961.34 Da        Isoelectric Point: 5.0651

>AT275031 WP_000212724.1 NZ_CP120397:c3965237-3964995 [Salmonella enterica subsp. enterica serovar Typhi]
MATLNVRLDDKLKNEAYAVLEKLNITPTEAVRLLFQYVAETGRMPVKTVTLSDSEDALIQTVRERLSSPQKGIKVSLDDL

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3Z1E876

Antitoxin

Source ID Structure
AlphaFold DB A0A5H5JRI5

References