Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) shpAB/BrnT-BrnA
Location 3862231..3862807 Replicon chromosome
Accession NZ_CP120397
Organism Salmonella enterica subsp. enterica serovar Typhi strain 1521-2017_CI

Toxin (Protein)


Gene name shpA Uniprot ID M7RG88
Locus tag PVA76_RS18975 Protein ID WP_001131963.1
Coordinates 3862520..3862807 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name shpB Uniprot ID B5R9R5
Locus tag PVA76_RS18970 Protein ID WP_000063142.1
Coordinates 3862231..3862533 (-) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PVA76_RS18955 (PVA76_18955) 3858741..3860891 + 2151 WP_000379928.1 pyruvate/proton symporter BtsT -
PVA76_RS18960 (PVA76_18960) 3860986..3861189 + 204 WP_000460616.1 YbdD/YjiX family protein -
PVA76_RS18965 (PVA76_18965) 3861200..3862156 + 957 WP_000187846.1 GTPase -
PVA76_RS18970 (PVA76_18970) 3862231..3862533 - 303 WP_000063142.1 BrnA antitoxin family protein Antitoxin
PVA76_RS18975 (PVA76_18975) 3862520..3862807 - 288 WP_001131963.1 BrnT family toxin Toxin
PVA76_RS18980 (PVA76_18980) 3863060..3863974 - 915 WP_000290515.1 restriction endonuclease -
PVA76_RS18985 (PVA76_18985) 3864172..3867681 + 3510 WP_001043493.1 type I restriction-modification system endonuclease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Ribonuclease toxin, BrnT, of type II toxin-antitoxin system

(7-88)

Antitoxin

BrnA antitoxin of type II toxin-antitoxin system

(37-93)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11294.80 Da        Isoelectric Point: 9.5894

>T275030 WP_001131963.1 NZ_CP120397:c3862807-3862520 [Salmonella enterica subsp. enterica serovar Typhi]
MPMEFEWDANKAKSNLRKHGVRFEDAVLVFDDPRHLSRQERYENGEYRWQTLGLVHGIVVILVAHSVRFESGFEVIRIIS
ARKADRKERNRYEHG

Download         Length: 288 bp

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11373.96 Da        Isoelectric Point: 10.1293

>AT275030 WP_000063142.1 NZ_CP120397:c3862533-3862231 [Salmonella enterica subsp. enterica serovar Typhi]
MSMVKHKRGNASALSAQHEAELKALAKKSDDEIDYSDIPASEDGQWSEAVRGKFFRPLKTQASVRIDADVMEWLKRPGKG
YQTRLNAILREAMLREQNKK

Download         Length: 303 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7VD7

Antitoxin

Source ID Structure
PDB 7VD7
AlphaFold DB A0A4D6PB01

References