Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1367783..1368403 Replicon chromosome
Accession NZ_CP120397
Organism Salmonella enterica subsp. enterica serovar Typhi strain 1521-2017_CI

Toxin (Protein)


Gene name Hha Uniprot ID V1H8E6
Locus tag PVA76_RS06550 Protein ID WP_001280991.1
Coordinates 1367783..1368001 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID V1H4V6
Locus tag PVA76_RS06555 Protein ID WP_000344807.1
Coordinates 1368029..1368403 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PVA76_RS06510 (PVA76_06510) 1363006..1363575 + 570 WP_000779802.1 YbaY family lipoprotein -
PVA76_RS06515 (PVA76_06515) 1363608..1363997 - 390 WP_000961285.1 MGMT family protein -
PVA76_RS06525 (PVA76_06525) 1364228..1365778 - 1551 WP_000213129.1 EAL domain-containing protein -
PVA76_RS06530 (PVA76_06530) 1366003..1366263 + 261 WP_000801415.1 type B 50S ribosomal protein L31 -
PVA76_RS06535 (PVA76_06535) 1366269..1366409 + 141 WP_001197749.1 type B 50S ribosomal protein L36 -
PVA76_RS06540 (PVA76_06540) 1366465..1366935 - 471 WP_000136183.1 YlaC family protein -
PVA76_RS06545 (PVA76_06545) 1367053..1367604 - 552 WP_001278793.1 maltose O-acetyltransferase -
PVA76_RS06550 (PVA76_06550) 1367783..1368001 - 219 WP_001280991.1 HHA domain-containing protein Toxin
PVA76_RS06555 (PVA76_06555) 1368029..1368403 - 375 WP_000344807.1 Hha toxicity modulator TomB Antitoxin
PVA76_RS06560 (PVA76_06560) 1368899..1372048 - 3150 WP_001132507.1 efflux RND transporter permease AcrB -
PVA76_RS06565 (PVA76_06565) 1372071..1373264 - 1194 WP_001039199.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8613.97 Da        Isoelectric Point: 8.9008

>T275025 WP_001280991.1 NZ_CP120397:c1368001-1367783 [Salmonella enterica subsp. enterica serovar Typhi]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14453.27 Da        Isoelectric Point: 5.1444

>AT275025 WP_000344807.1 NZ_CP120397:c1368403-1368029 [Salmonella enterica subsp. enterica serovar Typhi]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYNEDNKLIAQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4ICG

Antitoxin

Source ID Structure
AlphaFold DB A0A5I5FGI0

References