Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | tacAT/DUF1778(antitoxin) |
| Location | 953137..953951 | Replicon | chromosome |
| Accession | NZ_CP120397 | ||
| Organism | Salmonella enterica subsp. enterica serovar Typhi strain 1521-2017_CI | ||
Toxin (Protein)
| Gene name | TacT3 | Uniprot ID | Q57KM2 |
| Locus tag | PVA76_RS04520 | Protein ID | WP_000971655.1 |
| Coordinates | 953137..953664 (-) | Length | 176 a.a. |
Antitoxin (Protein)
| Gene name | TacA3 | Uniprot ID | M7S6I2 |
| Locus tag | PVA76_RS04525 | Protein ID | WP_000855694.1 |
| Coordinates | 953661..953951 (-) | Length | 97 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| PVA76_RS04500 (PVA76_04500) | 948345..950912 | - | 2568 | WP_001005807.1 | DNA mismatch repair protein MutS | - |
| PVA76_RS04505 (PVA76_04505) | 951070..951590 | + | 521 | Protein_880 | cytoplasmic protein | - |
| PVA76_RS04510 (PVA76_04510) | 951760..952416 | - | 657 | WP_000420463.1 | protein-serine/threonine phosphatase | - |
| PVA76_RS04515 (PVA76_04515) | 952643..953064 | + | 422 | Protein_882 | IS5/IS1182 family transposase | - |
| PVA76_RS04520 (PVA76_04520) | 953137..953664 | - | 528 | WP_000971655.1 | GNAT family N-acetyltransferase | Toxin |
| PVA76_RS04525 (PVA76_04525) | 953661..953951 | - | 291 | WP_000855694.1 | DUF1778 domain-containing protein | Antitoxin |
| PVA76_RS04530 (PVA76_04530) | 954221..954421 | - | 201 | Protein_885 | transposase | - |
| PVA76_RS04535 (PVA76_04535) | 954825..955268 | - | 444 | WP_000715096.1 | SPI-1 type III secretion system invasion lipoprotein InvH | - |
| PVA76_RS04540 (PVA76_04540) | 955724..956374 | + | 651 | WP_001674874.1 | type III secretion system transcriptional activator InvF | - |
| PVA76_RS04545 (PVA76_04545) | 956371..958059 | + | 1689 | WP_000848103.1 | type III secretion system outer membrane ring protein InvG | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Genomic island | - | invH / invF / invG / invE / invA / invB | 951760..961687 | 9927 | |
| - | flank | IS/Tn | - | - | 952918..953064 | 146 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 176 a.a. Molecular weight: 19069.91 Da Isoelectric Point: 9.6420
>T275024 WP_000971655.1 NZ_CP120397:c953664-953137 [Salmonella enterica subsp. enterica serovar Typhi]
MMFTDWHEAAIGKTHNRMNFDCGDADLNQFLQRHARQNHEKGTTKTYVALDNSDVTRIHGFYSVSPASLIYAQVPGAISK
GLGRYDVPVFRLGRLAVDKSMQGQGLGAQLLLSAGKRCIQAALQVGGVALLIDAKNKQVCDWYKGFGAVPLNDQPLSLLL
SFKTLYAALSASGRL
MMFTDWHEAAIGKTHNRMNFDCGDADLNQFLQRHARQNHEKGTTKTYVALDNSDVTRIHGFYSVSPASLIYAQVPGAISK
GLGRYDVPVFRLGRLAVDKSMQGQGLGAQLLLSAGKRCIQAALQVGGVALLIDAKNKQVCDWYKGFGAVPLNDQPLSLLL
SFKTLYAALSASGRL
Download Length: 528 bp
Antitoxin
Download Length: 97 a.a. Molecular weight: 10664.50 Da Isoelectric Point: 6.3133
>AT275024 WP_000855694.1 NZ_CP120397:c953951-953661 [Salmonella enterica subsp. enterica serovar Typhi]
MKTMPQIAIESNERLSLRVSTDAKKLIVRAAAIQQTNLTDFVVSNVLPVAQKIVDAAERVYLTERDTQMIMEILDNPPAP
NEKLLAAAFALPDMKK
MKTMPQIAIESNERLSLRVSTDAKKLIVRAAAIQQTNLTDFVVSNVLPVAQKIVDAAERVYLTERDTQMIMEILDNPPAP
NEKLLAAAFALPDMKK
Download Length: 291 bp
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| PDB | 6G96 | |
| PDB | 7AK9 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A3V8SJE7 |