Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 799616..800241 Replicon chromosome
Accession NZ_CP120397
Organism Salmonella enterica subsp. enterica serovar Typhi strain 1521-2017_CI

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag PVA76_RS03800 Protein ID WP_000911334.1
Coordinates 799843..800241 (+) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID M7S3S8
Locus tag PVA76_RS03795 Protein ID WP_000557549.1
Coordinates 799616..799843 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PVA76_RS03765 (PVA76_03765) 794787..795506 + 720 WP_000082599.1 Rha family transcriptional regulator -
PVA76_RS03770 (PVA76_03770) 795510..795713 + 204 WP_000184036.1 hypothetical protein -
PVA76_RS03775 (PVA76_03775) 795796..796251 + 456 WP_223229661.1 hypothetical protein -
PVA76_RS03780 (PVA76_03780) 796353..797474 + 1122 WP_000028980.1 hypothetical protein -
PVA76_RS03785 (PVA76_03785) 798107..798913 - 807 WP_077905073.1 DUF1460 domain-containing protein -
PVA76_RS03790 (PVA76_03790) 799188..799439 - 252 WP_001540858.1 hypothetical protein -
PVA76_RS03795 (PVA76_03795) 799616..799843 + 228 WP_000557549.1 toxin-antitoxin system antitoxin VapB Antitoxin
PVA76_RS03800 (PVA76_03800) 799843..800241 + 399 WP_000911334.1 tRNA(fMet)-specific endonuclease VapC Toxin
PVA76_RS03805 (PVA76_03805) 801048..801584 + 537 WP_001038500.1 STM3031 family outer membrane protein -
PVA76_RS03810 (PVA76_03810) 801631..802263 + 633 WP_000835268.1 YfdX family protein -
PVA76_RS03815 (PVA76_03815) 802982..803563 + 582 WP_001244646.1 fimbrial protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-123)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 15091.44 Da        Isoelectric Point: 7.7785

>T275023 WP_000911334.1 NZ_CP120397:799843-800241 [Salmonella enterica subsp. enterica serovar Typhi]
MLKFMLDTNTCIFTIKNKPEHIRERFNLNTSRMCISSITLMELIYGAEKSLAPERNFAVVEGFISRLEVLDYDTQAAIHT
GQIRTELARKGTPVGSYDQMIAGHARSRGLVVVTNNLREFERIPGIRIEDWC

Download         Length: 399 bp

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8514.51 Da        Isoelectric Point: 5.0210

>AT275023 WP_000557549.1 NZ_CP120397:799616-799843 [Salmonella enterica subsp. enterica serovar Typhi]
MHTTLFFSNRTQAVRLPKSISFPEDVKHVEIIAVGRSRIITPVGESWDSWFDGEGASTDFMSTREQPAVQEREGF

Download         Length: 228 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
PDB 6IFM
AlphaFold DB A0A3V2Y5V5

References