Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 204809..205569 Replicon chromosome
Accession NZ_CP120397
Organism Salmonella enterica subsp. enterica serovar Typhi strain 1521-2017_CI

Toxin (Protein)


Gene name tacT Uniprot ID Q8Z2B1
Locus tag PVA76_RS00960 Protein ID WP_000533908.1
Coordinates 205084..205569 (+) Length 162 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID Q8Z2B2
Locus tag PVA76_RS00955 Protein ID WP_000965889.1
Coordinates 204809..205096 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PVA76_RS00935 (PVA76_00935) 200214..201125 + 912 WP_001168555.1 glycine--tRNA ligase subunit alpha -
PVA76_RS00940 (PVA76_00940) 201135..203204 + 2070 WP_001291805.1 glycine--tRNA ligase subunit beta -
PVA76_RS00945 (PVA76_00945) 203594..204022 + 429 Protein_187 IS3 family transposase -
PVA76_RS00950 (PVA76_00950) 204164..204631 + 468 WP_000702452.1 GNAT family N-acetyltransferase -
PVA76_RS00955 (PVA76_00955) 204809..205096 + 288 WP_000965889.1 DUF1778 domain-containing protein Antitoxin
PVA76_RS00960 (PVA76_00960) 205084..205569 + 486 WP_000533908.1 GNAT family N-acetyltransferase Toxin
PVA76_RS00965 (PVA76_00965) 205940..206479 - 540 WP_000047148.1 copper-binding periplasmic metallochaperone CueP -
PVA76_RS00970 (PVA76_00970) 206655..206867 - 213 WP_000014594.1 RNA chaperone/antiterminator CspA -
PVA76_RS00975 (PVA76_00975) 207158..207445 - 288 Protein_193 HTH-type transcriptional regulator -
PVA76_RS00980 (PVA76_00980) 207884..208594 + 711 WP_000190524.1 DUF3053 domain-containing protein -
PVA76_RS00985 (PVA76_00985) 208644..209618 - 975 WP_000804690.1 glyoxylate/hydroxypyruvate reductase GhrB -
PVA76_RS00990 (PVA76_00990) 209837..210499 - 663 WP_000747548.1 OmpA family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(31-152)

Antitoxin

Vibrio phage ICP1, Orf50

(13-89)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17689.38 Da        Isoelectric Point: 9.8719

>T275019 WP_000533908.1 NZ_CP120397:205084-205569 [Salmonella enterica subsp. enterica serovar Typhi]
VGRVTAPEPLSAFHQVAEFVSGEAVLDDWLKQKGLKNQALGAARTFVVCKKDTKQVAGFYSLATGSVNHTEATGNLRRNM
PDPIPVIILARLAVDLSFHGKGLGADLLHDAVLRCYRVAENIGVRAIMVHALTEDAKNFYIHHGFKSSQTQQRTLFLRLP
Q

Download         Length: 486 bp

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10964.59 Da        Isoelectric Point: 4.6811

>AT275019 WP_000965889.1 NZ_CP120397:204809-205096 [Salmonella enterica subsp. enterica serovar Typhi]
MLYKGCLMKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILETACRAAENVILDRRVFNFNDEQYEEFINLLDAPVADD
PVIEKLLARKPQWDV

Download         Length: 288 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A714MHS9

Antitoxin

Source ID Structure
AlphaFold DB A0A752RW74

References