Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1367789..1368409 Replicon chromosome
Accession NZ_CP120396
Organism Salmonella enterica subsp. enterica serovar Typhi strain 1521-2017_CO_04

Toxin (Protein)


Gene name Hha Uniprot ID V1H8E6
Locus tag PVA80_RS06520 Protein ID WP_001280991.1
Coordinates 1367789..1368007 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID V1H4V6
Locus tag PVA80_RS06525 Protein ID WP_000344807.1
Coordinates 1368035..1368409 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PVA80_RS06480 (PVA80_06480) 1363012..1363581 + 570 WP_000779802.1 YbaY family lipoprotein -
PVA80_RS06485 (PVA80_06485) 1363614..1364003 - 390 WP_000961285.1 MGMT family protein -
PVA80_RS06495 (PVA80_06495) 1364234..1365784 - 1551 WP_000213129.1 EAL domain-containing protein -
PVA80_RS06500 (PVA80_06500) 1366009..1366269 + 261 WP_000801415.1 type B 50S ribosomal protein L31 -
PVA80_RS06505 (PVA80_06505) 1366275..1366415 + 141 WP_001197749.1 type B 50S ribosomal protein L36 -
PVA80_RS06510 (PVA80_06510) 1366471..1366941 - 471 WP_000136183.1 YlaC family protein -
PVA80_RS06515 (PVA80_06515) 1367059..1367610 - 552 WP_001278793.1 maltose O-acetyltransferase -
PVA80_RS06520 (PVA80_06520) 1367789..1368007 - 219 WP_001280991.1 HHA domain-containing protein Toxin
PVA80_RS06525 (PVA80_06525) 1368035..1368409 - 375 WP_000344807.1 Hha toxicity modulator TomB Antitoxin
PVA80_RS06530 (PVA80_06530) 1368905..1372054 - 3150 WP_001132507.1 efflux RND transporter permease AcrB -
PVA80_RS06535 (PVA80_06535) 1372077..1373270 - 1194 WP_001039199.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8613.97 Da        Isoelectric Point: 8.9008

>T275009 WP_001280991.1 NZ_CP120396:c1368007-1367789 [Salmonella enterica subsp. enterica serovar Typhi]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14453.27 Da        Isoelectric Point: 5.1444

>AT275009 WP_000344807.1 NZ_CP120396:c1368409-1368035 [Salmonella enterica subsp. enterica serovar Typhi]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYNEDNKLIAQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4ICG

Antitoxin

Source ID Structure
AlphaFold DB A0A5I5FGI0

References